X Chromosome Dose and Sex Bias in Autoimmune Diseases

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Fältnamn	Indikatorer	Metadata
000		11999naa a2201225 4500
001		oai:DiVA.org:liu-128940
003		SwePub
008		160607s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1289402 URI
024	7	a https://doi.org/10.1002/art.395602 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Liu, Keu University of Cincinnati, OH USA; Cincinnati Childrens Hospital Medical Centre, OH 45229 USA4 aut
245	1 0	a X Chromosome Dose and Sex Bias in Autoimmune Diseases
264	1	b WILEY-BLACKWELL,c 2016
338		a print2 rdacarrier
500		a Funding Agencies\|NIH [AR-062755, AI-024717, AI-031584, AI-062629, AI-063274, AI-082714, AI-083194, AI-101934]; NIH (National Institute of Dental and Craniofacial Research Intramural Research Program); University of Oklahoma Health Sciences Center (Clinical and Translational Science OCTSI Summer Scholar Program); US Department of Veterans Affairs [IMMA9]; US Department of Defense [PR094002]; Alliance for Lupus Research; Kirkland Scholar Program; Strategic Research Program at Helse Bergen; Western Norway Regional Health Authority; Broegelmann Foundation; French Ministry of Health (EvASSESS Programme Hospitalier de Recherche Clinique); Swedish Rheumatism Foundation; Arthritis Australia; Research to Prevent Blindness; Medical Research Council, UK [G0800629]; DFG [KFO 250 WI 1031/6-1]; Canadian Institutes of Health Research [MOP89955, MOP74621]; Ontario Research Fund [RE05-075]; Canada Research Chair Program; Instituto de Salud Carlos III (ISCIII through FEDER) [02558]; Allergan; Lilly; UCB; The NIH [AR-042460, AR-048204, AR-048940, AR-049084, AR-052125, AR-053483, AR-053734, AR-056360, AR-058959, AR-062277, AR-043814, AR-065626, DE-015223, DE-018209, RR-020143, GM-103510, GM-104938, HG-008667, TR-001475, HG-006828]
520		a Objective. More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47, XXX; occurring in similar to 1 in 1,000 live female births) would be increased in patients with female-predominant diseases (systemic lupus erythematosus [SLE], primary Sjogrens syndrome [SS], primary biliary cirrhosis, and rheumatoid arthritis [RA]) compared to patients with diseases without female predominance (sarcoidosis) and compared to controls. Methods. All subjects in this study were female. We identified subjects with 47, XXX using aggregate data from single-nucleotide polymorphism arrays, and, when possible, we confirmed the presence of 47, XXX using fluorescence in situ hybridization or quantitative polymerase chain reaction. Results. We found 47, XXX in 7 of 2,826 SLE patients and in 3 of 1,033 SS patients, but in only 2 of 7,074 controls (odds ratio in the SLE and primary SS groups 8.78 [95% confidence interval 1.67-86.79], P = 0.003 and odds ratio 10.29 [95% confidence interval 1.18-123.47], P = 0.02, respectively). One in 404 women with SLE and 1 in 344 women with SS had 47, XXX. There was an excess of 47, XXX among SLE and SS patients. Conclusion. The estimated prevalence of SLE and SS in women with 47, XXX was similar to 2.5 and similar to 2.9 times higher, respectively, than that in women with 46, XX and similar to 25 and similar to 41 times higher, respectively, than that in men with 46, XY. No statistically significant increase of 47, XXX was observed in other female-biased diseases (primary biliary cirrhosis or RA), supporting the idea of multiple pathways to sex bias in autoimmunity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700	1	a Kurien, Biji T.u University of Oklahoma, OK 73190 USA; Oklahoma City VA Medical Centre, OK USA4 aut
700	1	a Zimmerman, Sarah L.u Cincinnati Childrens Hospital Medical Centre, OH 45229 USA4 aut
700	1	a Kaufman, Kenneth M.u Cincinnati Childrens Hospital Medical Centre, OH 45229 USA; Cincinnati VA Medical Centre, OH USA4 aut
700	1	a Taft, Diana H.u Cincinnati Childrens Hospital Medical Centre, OH 45229 USA4 aut
700	1	a Kottyan, Leah C.u Cincinnati Childrens Hospital Medical Centre, OH 45229 USA4 aut
700	1	a Lazaro, Sarau Cincinnati Childrens Hospital Medical Centre, OH 45229 USA4 aut
700	1	a Weaver, Carrie A.u Cincinnati Childrens Hospital Medical Centre, OH 45229 USA4 aut
700	1	a Ice, John A.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Adler, Adam J.u Oklahoma City VA Medical Centre, OK USA; Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Chodosh, Jamesu Massachusetts Eye and Ear Infirm, MA 02114 USA; Harvard University, MA USA4 aut
700	1	a Radfar, Lidau University of Oklahoma, OK USA; University of Oklahoma, OK USA4 aut
700	1	a Rasmussen, Astridu Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Stone, Donald U.u University of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA4 aut
700	1	a Lewis, David M.u University of Oklahoma, OK USA; University of Oklahoma, OK USA4 aut
700	1	a Li, Shibou University of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA4 aut
700	1	a Koelsch, Kristi A.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Igoe, Annu Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Talsania, Mitaliu University of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA4 aut
700	1	a Kumar, Jayu Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Maier-Moore, Jacen S.u University of Oklahoma, OK 73190 USA; Oklahoma City VA Medical Centre, OK USA; University of Texas El Paso, TX 79968 USA4 aut
700	1	a Harris, Valerie M.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Gopalakrishnan, Rajaramu University of Minnesota, MN USA4 aut
700	1	a Jonsson, Rolandu University of Bergen, Norway; Haukeland Hospital, Norway4 aut
700	1	a Lessard, James A.u Valley Bone and Joint Clin, ND USA4 aut
700	1	a Lu, Xianglanu University of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA4 aut
700	1	a -Eric Gottenberg, Jacquesu Strasbourg University, France4 aut
700	1	a -Manuel Anaya, Juanu University of Rosario, Colombia4 aut
700	1	a Cunninghame-Graham, Deborah S.u Kings Coll London, England4 aut
700	1	a Huang, Andrew J. W.u University of Minnesota, MN USA4 aut
700	1	a Brennan, Michael T.u Carolinas Medical Centre, NC 28203 USA4 aut
700	1	a Hughes, Pamelau University of Minnesota, MN USA4 aut
700	1	a Mei, Gabor G.u MedImmune, MD USA; National Institute Dent and Craniofacial Research, MD USA4 aut
700	1	a Miceli-Richard, Corinneu University of Paris 11, France; INSERM, France4 aut
700	1	a Keystone, Edward C.u Mt Sinai Hospital, Canada; University of Toronto, Canada4 aut
700	1	a Bykerk, Vivian P.u Mt Sinai Hospital, Canada; University of Toronto, Canada; Hospital Special Surg, NY 10021 USA; Weill Cornell Med, NY USA4 aut
700	1	a Hirschfield, Gideonu University of Birmingham, England4 aut
700	1	a Xie, Gangu Mt Sinai Hospital, Canada; University of Toronto, Canada; Toronto Gen Hospital, Canada4 aut
700	1	a Ng, Wan-Faiu NIHR Newcastle Biomed Research Centre, England4 aut
700	1	a Nordmark, Gunnelu Uppsala University, Sweden4 aut
700	1	a Eriksson, Per,d 1958-u Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Avdelningen för inflammation och infektion,Region Östergötland, Reumatologiska kliniken i Östergötland,Region Östergötland, Reumatologiska kliniken i Östergötland,Newcastle University, England4 aut0 (Swepub:liu)perer22
700	1	a Omda, Roaldu Stavanger University Hospital, Norway4 aut
700	1	a Rhodus, Nelson L.u University of Minnesota, MN 55455 USA4 aut
700	1	a Rischmueller, Maureenu Queen Elizabeth Hospital, Australia; University of Adelaide, Australia4 aut
700	1	a Rohrer, Michaelu University of Minnesota, MN USA4 aut
700	1	a Sega, Barbara M.u University of Minnesota, MN 55455 USA; Hennepin County Medical Centre, MN 55415 USA4 aut
700	1	a Vvse, Timothy J.u Kings Coll London, England4 aut
700	1	a Wahren-Herlenius, Marieu Karolinska Institute, Sweden4 aut
700	1	a Witte, Torstenu Hannover Medical Sch, Germany4 aut
700	1	a Pons-Este, Bernardou Sanatorio Parque, Argentina4 aut
700	1	a Alarcon-Riquelme, Marta E.u Oklahoma Medical Research Fdn, OK 73104 USA; Centre Pfizer University of Granada Junta de Andalucia Genom, Spain4 aut
700	1	a Guthridge, Joel M.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a James, Judith A.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Lessard, Christopher J.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Kelly, Jennifer A.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Thompson, Susan D.u University of Cincinnati, OH USA; Cincinnati Childrens Hospital Medical Centre, OH 45229 USA4 aut
700	1	a Gaffney, Patrick M.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Montgomery, Courtney G.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Edberg, Jeffrey C.u University of Alabama Birmingham, AL USA4 aut
700	1	a Kimberly, Robert P.u University of Alabama Birmingham, AL USA4 aut
700	1	a Alarcon, Gracicla S.u University of Alabama Birmingham, AL USA4 aut
700	1	a Langefeld, Carl L.u Wake Forest University, NC 27109 USA4 aut
700	1	a Gilkeson, Gary S.u Medical University of S Carolina, SC USA4 aut
700	1	a Kamen, Diane L.u Medical University of S Carolina, SC USA4 aut
700	1	a Tsao, Betty P.u University of Calif Los Angeles, CA 90095 USA4 aut
700	1	a Joseph McCune, W.u University of Michigan, MI 48109 USA4 aut
700	1	a Salmon, Jane E.u Hospital Special Surg, NY 10021 USA; Weill Cornell Med, NY USA4 aut
700	1	a Merrill, Joan T.u University of Oklahoma, OK USA; University of Oklahoma, OK 73190 USA4 aut
700	1	a Weisman, Michael H.u Cedars Sinai Medical Centre, CA 90048 USA4 aut
700	1	a Wallace, Daniel J.u Cedars Sinai Medical Centre, CA 90048 USA; University of Calif Los Angeles, CA 90095 USA4 aut
700	1	a Utset, Tammyu University of Chicago, IL 60637 USA4 aut
700	1	a Bottinger, Erwin P.u Mt Sinai Hospital, NY 10029 USA4 aut
700	1	a Amos, Christopher I.u Dartmouth Coll, NH 03755 USA4 aut
700	1	a Siminovitch, Katherine A.u Mt Sinai Hospital, Canada; University of Toronto, Canada; Toronto Gen Hospital, Canada4 aut
700	1	a Mariette, Xavieru University of Paris 11, France; INSERM, France4 aut
700	1	a Sivils, Kathy L.u Oklahoma Medical Research Fdn, OK 73104 USA4 aut
700	1	a Harley, John B.u University of Cincinnati, OH USA; Cincinnati Childrens Hospital Medical Centre, OH 45229 USA; Cincinnati VA Medical Centre, OH USA4 aut
700	1	a Hal Scofield, R.u University of Oklahoma, OK 73190 USA; Oklahoma City VA Medical Centre, OK USA4 aut
710	2	a University of Cincinnati, OH USA; Cincinnati Childrens Hospital Medical Centre, OH 45229 USAb University of Oklahoma, OK 73190 USA; Oklahoma City VA Medical Centre, OK USA4 org
773	0	t Arthritis & Rheumatologyd : WILEY-BLACKWELLg 68:5, s. 1290-1300q 68:5<1290-1300x 2326-5191x 2326-5205
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.39560
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128940
856	4 8	u https://doi.org/10.1002/art.39560

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Av författaren/redakt...: Liu, Ke; Kurien, Biji T.; Zimmerman, Sarah ...; Kaufman, Kenneth ...; Taft, Diana H.; Kottyan, Leah C.; visa fler...; Lazaro, Sara; Weaver, Carrie A ...; Ice, John A.; Adler, Adam J.; Chodosh, James; Radfar, Lida; Rasmussen, Astri ...; Stone, Donald U.; Lewis, David M.; Li, Shibo; Koelsch, Kristi ...; Igoe, Ann; Talsania, Mitali; Kumar, Jay; Maier-Moore, Jac ...; Harris, Valerie ...; Gopalakrishnan, ...; Jonsson, Roland; Lessard, James A ...; Lu, Xianglan; -Eric Gottenberg ...; -Manuel Anaya, J ...; Cunninghame-Grah ...; Huang, Andrew J. ...; Brennan, Michael ...; Hughes, Pamela; Mei, Gabor G.; Miceli-Richard, ...; Keystone, Edward ...; Bykerk, Vivian P ...; Hirschfield, Gid ...; Xie, Gang; Ng, Wan-Fai; Nordmark, Gunnel; Eriksson, Per, 1 ...; Omda, Roald; Rhodus, Nelson L ...; Rischmueller, Ma ...; Rohrer, Michael; Sega, Barbara M.; Vvse, Timothy J.; Wahren-Herlenius ...; Witte, Torsten; Pons-Este, Berna ...; Alarcon-Riquelme ...; Guthridge, Joel ...; James, Judith A.; Lessard, Christo ...; Kelly, Jennifer ...; Thompson, Susan ...; Gaffney, Patrick ...; Montgomery, Cour ...; Edberg, Jeffrey ...; Kimberly, Robert ...; Alarcon, Gracicl ...; Langefeld, Carl ...; Gilkeson, Gary S ...; Kamen, Diane L.; Tsao, Betty P.; Joseph McCune, W ...; Salmon, Jane E.; Merrill, Joan T.; Weisman, Michael ...; Wallace, Daniel ...; Utset, Tammy; Bottinger, Erwin ...; Amos, Christophe ...; Siminovitch, Kat ...; Mariette, Xavier; Sivils, Kathy L.; Harley, John B.; Hal Scofield, R.; visa färre...

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