SwePub
Sök i LIBRIS databas

  Utökad sökning

(WFRF:(Rosa G.)) srt2:(2000-2004)
 

Sökning: (WFRF:(Rosa G.)) srt2:(2000-2004) > (2000) > Somatic deletions i...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004944naa a2200661 4500
001oai:lup.lub.lu.se:bcedee37-2c89-4cbe-bc93-20d5819a577c
003SwePub
008160401s2000 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/11168012 URI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Kainu, T4 aut
2451 0a Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus
264 1c 2000
520 a A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We applied a strategy to identify predisposition loci for breast cancer by using mathematical models to identify early somatic genetic deletions in tumor tissues followed by targeted linkage analysis. Comparative genomic hybridization was used to study 61 breast tumors from 37 breast cancer families with no identified BRCA1 or BRCA2 mutations. Branching and phylogenetic tree models predicted that loss of 13q was one of the earliest genetic events in hereditary cancers. In a Swedish family with five breast cancer cases, all analyzed tumors showed distinct 13q deletions, with the minimal region of loss at 13q21-q22. Genotyping revealed segregation of a shared 13q21 germ-line haplotype in the family. Targeted linkage analysis was carried out in a set of 77 Finnish, Icelandic, and Swedish breast cancer families with no detected BRCA1 and BRCA2 mutations. A maximum parametric two-point logarithm of odds score of 2.76 was obtained for a marker at 13q21 (D13S1308, theta = 0.10). The multipoint logarithm of odds score under heterogeneity was 3.46. The results were further evaluated by simulation to assess the probability of obtaining significant evidence in favor of linkage by chance as well as to take into account the possible influence of the BRCA2 locus, located at a recombination fraction of 0.25 from the new locus. The simulation substantiated the evidence of linkage at D13S1308 (P < 0.0017). The results warrant studies of this putative breast cancer predisposition locus in other populations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Juo, S H4 aut
7001 a Desper, R4 aut
7001 a Schaffer, A A4 aut
7001 a Gillanders, E4 aut
7001 a Rozenblum, E4 aut
7001 a Freas-Lutz, D4 aut
7001 a Weaver, D4 aut
7001 a Stephan, D4 aut
7001 a Bailey-Wilson, J4 aut
7001 a Kallioniemi, O P4 aut
7001 a Tirkkonen, M4 aut
7001 a Syrjakoski, K4 aut
7001 a Kuukasjarvi, T4 aut
7001 a Koivisto, P4 aut
7001 a Karhu, R4 aut
7001 a Holli, K4 aut
7001 a Arason, A4 aut
7001 a Johannesdottir, G4 aut
7001 a Bergthorsson, Jon Thor4 aut
7001 a Johannsdottir, Hrefna4 aut
7001 a Egilsson, Valgardur4 aut
7001 a Björk Barkardottir, Rosa4 aut
7001 a Johannsson, Oskar4 aut
7001 a Haraldsson, Karinu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-kha
7001 a Törngren, Thereseu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-tsa
7001 a Holmberg, Eva4 aut
7001 a Henrik Grönberg, Henrik4 aut
7001 a Olsson, Håkanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol
7001 a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo
7001 a Vehmanen, Paula4 aut
7001 a Eerola, Hannaleena4 aut
7001 a Heikkilä, Päivi4 aut
7001 a Pyrhönen, Seppo4 aut
7001 a Nevanlinna, Heli4 aut
7102 a Bröstcancer-genetikb Sektion I4 org
7730 t Proceedings of the National Academy of Sciencesg 97:17, s. 9603-9608q 97:17<9603-9608x 1091-6490
8564 u http://www.pnas.org/cgi/content/full/97/17/9603x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/1116801

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy