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Development of a no...
Development of a novel biomarker of free radical damage in reperfusion injury after cardiac arrest
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- Basu, Samar (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Nozari, A. (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care
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- Liu, X. L. (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care
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- Rubertsson, Sten (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Wiklund, Lars (author)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: FEBS Letters. - 0014-5793 .- 1873-3468. ; 470:1, s. 1-6
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In a porcine model of cardiopulmonary resuscitation (CPR), we investigated changes in the plasma levels of 8-iso-PGF(2alpha), a marker for oxidative injury, and 15-keto-dihydro-PGF(2alpha), an inflammatory response indicator during the post-resuscitation period after cardiac arrest. Twelve piglets were subjected to either 2 or 5 min (VF2 and VF5 group) of ventricular fibrillation (VF) followed by 5 min of closed-chest CPR. Six piglets without cardiac arrest were used as controls. In VF5 group, 8-iso-PGF(2alpha) in the jugular bulb plasma (draining the brain) increased four-fold. Jugular bulb 8-iso-PGF(2alpha) in the control group remained unchanged. The 15-keto-dihydro-PGF(2alpha) also increased four-fold in the VF5 group. Thus, 8-iso-PGF(2alpha) and 15-keto-dihydro-PGF(2alpha) measurements in jugular bulb plasma may be used as biomarkers for quantification of free radical catalyzed oxidative brain injury and inflammatory response in reperfusion injury
Keyword
- Isoprostane
- Prostaglandin
- Inflammation
- Oxidative stress
- Brain
- Cardiac arrest
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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