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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003710naa a2200517 4500
001oai:DiVA.org:su-87239
003SwePub
008130130s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:125898111
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-872392 URI
0247 a https://doi.org/10.1159/0003437762 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1258981112 URI
040 a (SwePub)sud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Clerici, Francesca4 aut
2451 0a Does Vascular Burden Contribute to the Progression of Mild Cognitive Impairment to Dementia?
264 c 2012-11-10
264 1b S. Karger AG,c 2012
338 a print2 rdacarrier
520 a Aims: To investigate the contribution of vascular risk factors (VRFs), vascular diseases (VDs) and white matter lesions (WMLs) to the progression of mild cognitive impairment (MCI) to dementia and Alzheimer’s disease (AD). Methods: Two hundred forty-five consecutive subjects with MCI (age 74.09 ± 6.92 years) were followed for an average of 2.4 years. The Hachinski Ischemic Score and the Framingham Stroke Risk Profile were used to summarize VRFs and VDs. WMLs were graded using the Age-Related White Matter Changes Scale. Results: One hundred twenty-nine (52.6%) out of 245 subjects at risk converted to dementia, including 87 cases of AD. When hypertension occurred in MCI with deep WMLs, a 1.8-fold increased risk of dementia was observed (95% CI = 1.0–3.4). When deep WMLs occurred in MCI with high scores (≥4) on the Hachinski scale, a 3.5-fold (95% CI = 1.6–7.4) and 3.8-fold (95% CI = 1.2–11.5) risk of progression to dementia and AD was observed, respectively. Analogously, the joint effect of WMLs and high scores (≥14) on the Framingham scale nearly doubled the risk of dementia (hazard ratio = 1.9, 95% CI = 1.1–3.3). Conclusions: Accelerated progression of MCI to dementia and AD is to be expected when VRFs and VDs occur together with WMLs.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653 a Cerebrovascular disease
653 a Hypertension
653 a Mild cognitive impairment
653 a Vascular burden
653 a Vascular risk factors
653 a Alzheimer’s disease
7001 a Caracciolo, Barbarau Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut0 (Swepub:su)bcara
7001 a Cova, Ilaria4 aut
7001 a Fusari Imperatori, Susanna4 aut
7001 a Maggiore, Laura4 aut
7001 a Galimberti, Daniela4 aut
7001 a Scarpini, Elio4 aut
7001 a Mariani, Claudio4 aut
7001 a Fratiglioni, Laurau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
7102 a Stockholms universitetb Stressforskningsinstitutet4 org
7730 t Dementia and Geriatric Cognitive Disordersd : S. Karger AGg 34:3-4, s. 235-243q 34:3-4<235-243x 1420-8008x 1421-9824
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-87239
8564 8u https://doi.org/10.1159/000343776
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:125898111

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