Search: (WFRF:(Scarpini Elio)) mspu:(article) > Does Vascular Burde...
Fältnamn | Indikatorer | Metadata |
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000 | 03710naa a2200517 4500 | |
001 | oai:DiVA.org:su-87239 | |
003 | SwePub | |
008 | 130130s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:125898111 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-872392 URI |
024 | 7 | a https://doi.org/10.1159/0003437762 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1258981112 URI |
040 | a (SwePub)sud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Clerici, Francesca4 aut |
245 | 1 0 | a Does Vascular Burden Contribute to the Progression of Mild Cognitive Impairment to Dementia? |
264 | c 2012-11-10 | |
264 | 1 | b S. Karger AG,c 2012 |
338 | a print2 rdacarrier | |
520 | a Aims: To investigate the contribution of vascular risk factors (VRFs), vascular diseases (VDs) and white matter lesions (WMLs) to the progression of mild cognitive impairment (MCI) to dementia and Alzheimer’s disease (AD). Methods: Two hundred forty-five consecutive subjects with MCI (age 74.09 ± 6.92 years) were followed for an average of 2.4 years. The Hachinski Ischemic Score and the Framingham Stroke Risk Profile were used to summarize VRFs and VDs. WMLs were graded using the Age-Related White Matter Changes Scale. Results: One hundred twenty-nine (52.6%) out of 245 subjects at risk converted to dementia, including 87 cases of AD. When hypertension occurred in MCI with deep WMLs, a 1.8-fold increased risk of dementia was observed (95% CI = 1.0–3.4). When deep WMLs occurred in MCI with high scores (≥4) on the Hachinski scale, a 3.5-fold (95% CI = 1.6–7.4) and 3.8-fold (95% CI = 1.2–11.5) risk of progression to dementia and AD was observed, respectively. Analogously, the joint effect of WMLs and high scores (≥14) on the Framingham scale nearly doubled the risk of dementia (hazard ratio = 1.9, 95% CI = 1.1–3.3). Conclusions: Accelerated progression of MCI to dementia and AD is to be expected when VRFs and VDs occur together with WMLs. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
653 | a Cerebrovascular disease | |
653 | a Hypertension | |
653 | a Mild cognitive impairment | |
653 | a Vascular burden | |
653 | a Vascular risk factors | |
653 | a Alzheimer’s disease | |
700 | 1 | a Caracciolo, Barbarau Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut0 (Swepub:su)bcara |
700 | 1 | a Cova, Ilaria4 aut |
700 | 1 | a Fusari Imperatori, Susanna4 aut |
700 | 1 | a Maggiore, Laura4 aut |
700 | 1 | a Galimberti, Daniela4 aut |
700 | 1 | a Scarpini, Elio4 aut |
700 | 1 | a Mariani, Claudio4 aut |
700 | 1 | a Fratiglioni, Laurau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
710 | 2 | a Stockholms universitetb Stressforskningsinstitutet4 org |
773 | 0 | t Dementia and Geriatric Cognitive Disordersd : S. Karger AGg 34:3-4, s. 235-243q 34:3-4<235-243x 1420-8008x 1421-9824 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-87239 |
856 | 4 8 | u https://doi.org/10.1159/000343776 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125898111 |
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