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FältnamnIndikatorerMetadata
00005434naa a2200685 4500
001oai:research.chalmers.se:889796af-8985-4cc0-8a26-044bf3e2e332
003SwePub
008171008s2016 | |||||||||||000 ||eng|
0247 a https://doi.org/10.1002/bem.219632 DOI
0247 a https://research.chalmers.se/publication/2356052 URI
040 a (SwePub)cth
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a vet2 swepub-contenttype
1001 a Schüz, Ju International Agency for Research on Cancer (IARC)4 aut
2451 0a Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium
264 c 2016-03-15
264 1b Wiley,c 2016
520 a Exposure to extremely low-frequency magnetic fields (ELF-MF) was evaluated in an International Agency for Research on Cancer (IARC) Monographs as possibly carcinogenic to humans in 2001, based on increased childhood leukemia risk observed in epidemiological studies. We conducted a hazard assessment using available scientific evidence published before March 2015, with inclusion of new research findings from the Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment (ARIMMORA) project. The IARC Monograph evaluation scheme was applied to hazard identification. In ARIMMORA for the first time, a transgenic mouse model was used to mimic the most common childhood leukemia: new pathogenic mechanisms were indicated, but more data are needed to draw definitive conclusions. Although experiments in different animal strains showed exposure-related decreases of CD8+ T-cells, a role in carcinogenesis must be further established. No direct damage of DNA by exposure was observed. Overall in the literature, there is limited evidence of carcinogenicity in humans and inadequate evidence of carcinogenicity in experimental animals, with only weak supporting evidence from mechanistic studies. New exposure data from ARIMMORA confirmed that if the association is nevertheless causal, up to 2% of childhood leukemias in Europe, as previously estimated, may be attributable to ELF-MF. In summary, ARIMMORA concludes that the relationship between ELF-MF and childhood leukemia remains consistent with possible carcinogenicity in humans. While this scientific uncertainty is dissatisfactory for science and public health, new mechanistic insight from ARIMMORA experiments points to future research that could provide a step-change in future assessments. Bioelectromagnetics. 37:183-189, 2016.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653 a risk assessment
653 a hazard identification
653 a acute lymphoblastic-leukemia
653 a fetal exposure
653 a cancer
653 a electromagnetic fields
653 a leukemia
653 a 
653 a pooled analysis
653 a children
653 a adverse effects
653 a electromagnetic-fields
7001 a Dasenbrock, C.u Fraunhofer Institut fur Toxikologie und Experimentelle Medizin - ITEM4 aut
7001 a Ravazzani, P.u Consiglo Nazionale Delle Richerche4 aut
7001 a Röösli, Mu Swiss Tropical and Public Health Institute (Swiss TPH)4 aut
7001 a Schar, P.u Universität Basel,University of Basel4 aut
7001 a Bounds, P. L.u Foundation for Research on Information Technologies in Society (ITIS)4 aut
7001 a Erdmann, F.u International Agency for Research on Cancer (IARC)4 aut
7001 a Borkhardt, A.u Heinrich Heine Universität Düsseldorf,Heinrich Heine University Düsseldorf4 aut
7001 a Cobaleda, C.u CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM)4 aut
7001 a Fedrowitz, M.4 aut
7001 a Hamnerius, Yngve,d 1950u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)elfyngve
7001 a Sanchez-Garcia, I.4 aut
7001 a Seger, R.u Weizmann Institute of Science4 aut
7001 a Schmiegelow, K.u Copenhagen University Hospital4 aut
7001 a Ziegelberger, G.u Bundesamt für Strahlenschutz (BfS)4 aut
7001 a Capstick, M.u Foundation for Research on Information Technologies in Society (ITIS)4 aut
7001 a Manser, M.u Universität Basel,University of Basel4 aut
7001 a Muller, M.u Fraunhofer Institut fur Toxikologie und Experimentelle Medizin - ITEM4 aut
7001 a Schmid, C. D.u Swiss Tropical and Public Health Institute (Swiss TPH)4 aut
7001 a Schurmann, D.u Universität Basel,University of Basel4 aut
7001 a Struchen, B.u Swiss Tropical and Public Health Institute (Swiss TPH)4 aut
7001 a Kuster, N.u Foundation for Research on Information Technologies in Society (ITIS)4 aut
7102 a International Agency for Research on Cancer (IARC)b Fraunhofer Institut fur Toxikologie und Experimentelle Medizin - ITEM4 org
7730 t Bioelectromagneticsd : Wileyg 37:3, s. 183-189q 37:3<183-189x 1521-186Xx 0197-8462
8564 u http://dx.doi.org/10.1002/bem.21963y FULLTEXT
8564 8u https://doi.org/10.1002/bem.21963
8564 8u https://research.chalmers.se/publication/235605

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