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Implementation of p...
Implementation of precision medicine in healthcare—A European perspective
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- Stenzinger, Albrecht (author)
- University Hospital Heidelberg
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Moltzen, Ejner K. (author)
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- Winkler, Eva (author)
- University Hospital Heidelberg
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- Molnar-Gabor, Fruzsina (author)
- Heidelberg University
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- Malek, Nisar (author)
- University Hospital of Tubingen
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- Costescu, Alexandru (author)
- European Commission
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Jensen, Brigitte Nybo (author)
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- Nowak, Frédérique (author)
- National Institute for Health and Medical Research, France
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Pinto, Carmine (author)
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- Ottersen, Ole Petter (author)
- Karolinska Institute
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- Schirmacher, Peter (author)
- University Hospital Heidelberg
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Nordborg, Jenni (author)
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- Seufferlein, Thomas (author)
- University Hospital of Ulm
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- Fröhling, Stefan (author)
- German Cancer Research Centre
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- Edsjö, Anders (author)
- Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne,Genomic Medicine Sweden (GMS)
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- Garcia-Foncillas, Jesus (author)
- Hospital Fundación Jiménez Díaz
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- Normanno, Nicola (author)
- Istituto Nazionale dei Tumori
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Lundgren, Bettina (author)
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- Friedman, Mikaela (author)
- Karolinska Institutet,Karolinska Institute,Genomic Medicine Sweden (GMS)
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Bolanos, Natacha (author)
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- Tatton-Brown, Katrina (author)
- National Health Service Trust, NHS England,St George's, University of London
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- Hill, Sue (author)
- National Health Service Trust, NHS England
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- Rosenquist, Richard (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Genomic Medicine Sweden (GMS)
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(creator_code:org_t)
- 2023
- 2023
- English 18 s.
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In: Journal of Internal Medicine. - 0954-6820 .- 1365-2796. ; 294:4, s. 437-454
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Abstract
Subject headings
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- The technical development of high-throughput sequencing technologies and the parallel development of targeted therapies in the last decade have enabled a transition from traditional medicine to personalized treatment and care. In this way, by using comprehensive genomic testing, more effective treatments with fewer side effects are provided to each patient—that is, precision or personalized medicine (PM). In several European countries—such as in England, France, Denmark, and Spain—the governments have adopted national strategies and taken “top-down” decisions to invest in national infrastructure for PM. In other countries—such as Sweden, Germany, and Italy with regionally organized healthcare systems—the profession has instead taken “bottom-up” initiatives to build competence networks and infrastructure to enable equal access to PM. In this review, we summarize key learnings at the European level on the implementation process to establish sustainable governance and organization for PM at the regional, national, and EU/international levels. We also discuss critical ethical and legal aspects of implementing PM, and the importance of access to real-world data and performing clinical trials for evidence generation, as well as the need for improved reimbursement models, increased cross-disciplinary education and patient involvement. In summary, PM represents a paradigm shift, and modernization of healthcare and all relevant stakeholders—that is, healthcare, academia, policymakers, industry, and patients—must be involved in this system transformation to create a sustainable, non-siloed ecosystem for precision healthcare that benefits our patients and society at large.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Keyword
- clinical trials
- education and training
- ethicolegal aspects
- governance
- patient advocacy
- personalized medicine
- precision medicine
- real-world evidence
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- ref (subject category)
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- By the author/editor
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Stenzinger, Albr ...
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Moltzen, Ejner K ...
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Winkler, Eva
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Molnar-Gabor, Fr ...
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Malek, Nisar
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Costescu, Alexan ...
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show more...
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Jensen, Brigitte ...
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Nowak, Frédériqu ...
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Pinto, Carmine
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Ottersen, Ole Pe ...
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Schirmacher, Pet ...
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Nordborg, Jenni
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Seufferlein, Tho ...
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Fröhling, Stefan
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Edsjö, Anders
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Garcia-Foncillas ...
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Normanno, Nicola
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Lundgren, Bettin ...
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Friedman, Mikael ...
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Bolanos, Natacha
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Tatton-Brown, Ka ...
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Hill, Sue
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Rosenquist, Rich ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Health Care Serv ...
- Articles in the publication
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Journal of Inter ...
- By the university
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Lund University
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Karolinska Institutet