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  • Rosenblatt, RobertUmeå universitet,Urologi och andrologi,Department of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Stockholm South Gen Hosp, Dept Urol, Stockholm, Sweden;Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden (author)

Sentinel node detection in muscle-invasive urothelial bladder cancer is feasible after neoadjuvant chemotherapy in all pT stages, a prospective multicenter report

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-10-13
  • Springer Science and Business Media LLC,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-127668
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127668URI
  • https://doi.org/10.1007/s00345-016-1952-xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361224URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135959463URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • PURPOSE: To determine whether sentinel node detection (SNd) in muscle-invasive urothelial bladder cancer (MIBC) can be performed in patients undergoing neoadjuvant chemotherapy (NAC) and determine whether SNd is feasible in all pT stages, including pT0.BACKGROUND: Previous published series of SNd in MIBC have not included patients undergoing NAC, and systematic reports of pT0 patients w/wo NAC were absent. Translational immunological tumor research on MIBC focusing on SNd, in the era of NAC, requires technical feasibility. Additionally, SNd in MIBC requests further evaluations as a method for nodal staging.MATERIALS AND METHODS: Ninety-nine patients with suspected urothelial MIBC were prospectively selected from six urological centers. After TUR-B and primary staging, 65 MIBC patients qualified for radical cystectomy. Precystectomy staging was cT2a-T4aN0M0, including 47 NAC patients and 18 chemo-naïve patients. All 65 patients underwent intraoperative SNd by peritumoral injection of 80 Mbq Technetium and Geiger probe detection. Postcystectomy staging was pT0-T4aN0-N2M0. SNs were defined by two calculations, SNdef1 and SNdef2.RESULTS: Totally 1063 lymph nodes were removed (total SNs; 222-227). NAC patients with pT0 (n = 24) displayed a true positive detection in 91.7 % by either SNdef, with a median of 3.0 SNs. NACpT >0 patients had a true positive detection in 87 % (SNdef1) and 91.3 % (SNdef2). In a univariate analysis, patient group neither NAC nor tumor downstaging influenced detection rates, regardless of SN definition. In total eight patients, 4/22 metastatic nodes were SNs while 18/22 were non-SNs.CONCLUSIONS: Sentinel node detection in MIBC is feasible also in NAC patients, regardless of pT stage. SNd played no role in nodal staging.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Johansson, MarkusSundsvall Hosp, Dept Urol, Sundsvall, Sweden (author)
  • Alamdari, FarhoodVastmanland Hosp, Dept Urol, Vasteras, Sweden (author)
  • Sidiki, AlexanderLanssjukhuset Ryhov, Dept Urol, Jonkoping, Sweden (author)
  • Holmström, BennyUppsala universitet,Urologkirurgi (author)
  • Hansson, Johan,1964-Uppsala universitet,Centrum för klinisk forskning, Gävleborg(Swepub:uu)johan031 (author)
  • Vasko, JanosUmeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, Umea, Sweden(Swepub:umu)jasvao04 (author)
  • Marits, PerKarolinska Institutet (author)
  • Gabrielsson, SusanneKarolinska Institutet (author)
  • Riklund, KatrineUmeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden(Swepub:umu)kaah0001 (author)
  • Winqvist, OlaKarolinska Institutet (author)
  • Sherif, AmirUmeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden(Swepub:umu)amsh0008 (author)
  • Umeå universitetUrologi och andrologi (creator_code:org_t)

Related titles

  • In:World journal of urology: Springer Science and Business Media LLC35:6, s. 921-9270724-49831433-8726

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