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Sentinel node detec...
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Rosenblatt, RobertUmeå universitet,Urologi och andrologi,Department of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Stockholm South Gen Hosp, Dept Urol, Stockholm, Sweden;Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden
(author)
Sentinel node detection in muscle-invasive urothelial bladder cancer is feasible after neoadjuvant chemotherapy in all pT stages, a prospective multicenter report
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2016-10-13
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Springer Science and Business Media LLC,2017
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-127668
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127668URI
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https://doi.org/10.1007/s00345-016-1952-xDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361224URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135959463URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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PURPOSE: To determine whether sentinel node detection (SNd) in muscle-invasive urothelial bladder cancer (MIBC) can be performed in patients undergoing neoadjuvant chemotherapy (NAC) and determine whether SNd is feasible in all pT stages, including pT0.BACKGROUND: Previous published series of SNd in MIBC have not included patients undergoing NAC, and systematic reports of pT0 patients w/wo NAC were absent. Translational immunological tumor research on MIBC focusing on SNd, in the era of NAC, requires technical feasibility. Additionally, SNd in MIBC requests further evaluations as a method for nodal staging.MATERIALS AND METHODS: Ninety-nine patients with suspected urothelial MIBC were prospectively selected from six urological centers. After TUR-B and primary staging, 65 MIBC patients qualified for radical cystectomy. Precystectomy staging was cT2a-T4aN0M0, including 47 NAC patients and 18 chemo-naïve patients. All 65 patients underwent intraoperative SNd by peritumoral injection of 80 Mbq Technetium and Geiger probe detection. Postcystectomy staging was pT0-T4aN0-N2M0. SNs were defined by two calculations, SNdef1 and SNdef2.RESULTS: Totally 1063 lymph nodes were removed (total SNs; 222-227). NAC patients with pT0 (n = 24) displayed a true positive detection in 91.7 % by either SNdef, with a median of 3.0 SNs. NACpT >0 patients had a true positive detection in 87 % (SNdef1) and 91.3 % (SNdef2). In a univariate analysis, patient group neither NAC nor tumor downstaging influenced detection rates, regardless of SN definition. In total eight patients, 4/22 metastatic nodes were SNs while 18/22 were non-SNs.CONCLUSIONS: Sentinel node detection in MIBC is feasible also in NAC patients, regardless of pT stage. SNd played no role in nodal staging.
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Johansson, MarkusSundsvall Hosp, Dept Urol, Sundsvall, Sweden
(author)
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Alamdari, FarhoodVastmanland Hosp, Dept Urol, Vasteras, Sweden
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Sidiki, AlexanderLanssjukhuset Ryhov, Dept Urol, Jonkoping, Sweden
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Holmström, BennyUppsala universitet,Urologkirurgi
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Hansson, Johan,1964-Uppsala universitet,Centrum för klinisk forskning, Gävleborg(Swepub:uu)johan031
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Vasko, JanosUmeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, Umea, Sweden(Swepub:umu)jasvao04
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Marits, PerKarolinska Institutet
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Gabrielsson, SusanneKarolinska Institutet
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Riklund, KatrineUmeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden(Swepub:umu)kaah0001
(author)
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Winqvist, OlaKarolinska Institutet
(author)
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Sherif, AmirUmeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden(Swepub:umu)amsh0008
(author)
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Umeå universitetUrologi och andrologi
(creator_code:org_t)
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In:World journal of urology: Springer Science and Business Media LLC35:6, s. 921-9270724-49831433-8726
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