Sökning: (WFRF:(Sidiki Alexander)) > (2017) > Sentinel node detec...
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003 | SwePub | |
008 | 161117s2017 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-361224 | |
009 | oai:prod.swepub.kib.ki.se:135959463 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1276682 URI |
024 | 7 | a https://doi.org/10.1007/s00345-016-1952-x2 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3612242 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1359594632 URI |
040 | a (SwePub)umud (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
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100 | 1 | a Rosenblatt, Robertu Umeå universitet,Urologi och andrologi,Department of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Stockholm South Gen Hosp, Dept Urol, Stockholm, Sweden;Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden4 aut0 (Swepub:umu)roro0025 |
245 | 1 0 | a Sentinel node detection in muscle-invasive urothelial bladder cancer is feasible after neoadjuvant chemotherapy in all pT stages, a prospective multicenter report |
264 | c 2016-10-13 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
338 | a electronic2 rdacarrier | |
520 | a PURPOSE: To determine whether sentinel node detection (SNd) in muscle-invasive urothelial bladder cancer (MIBC) can be performed in patients undergoing neoadjuvant chemotherapy (NAC) and determine whether SNd is feasible in all pT stages, including pT0.BACKGROUND: Previous published series of SNd in MIBC have not included patients undergoing NAC, and systematic reports of pT0 patients w/wo NAC were absent. Translational immunological tumor research on MIBC focusing on SNd, in the era of NAC, requires technical feasibility. Additionally, SNd in MIBC requests further evaluations as a method for nodal staging.MATERIALS AND METHODS: Ninety-nine patients with suspected urothelial MIBC were prospectively selected from six urological centers. After TUR-B and primary staging, 65 MIBC patients qualified for radical cystectomy. Precystectomy staging was cT2a-T4aN0M0, including 47 NAC patients and 18 chemo-naïve patients. All 65 patients underwent intraoperative SNd by peritumoral injection of 80 Mbq Technetium and Geiger probe detection. Postcystectomy staging was pT0-T4aN0-N2M0. SNs were defined by two calculations, SNdef1 and SNdef2.RESULTS: Totally 1063 lymph nodes were removed (total SNs; 222-227). NAC patients with pT0 (n = 24) displayed a true positive detection in 91.7 % by either SNdef, with a median of 3.0 SNs. NACpT >0 patients had a true positive detection in 87 % (SNdef1) and 91.3 % (SNdef2). In a univariate analysis, patient group neither NAC nor tumor downstaging influenced detection rates, regardless of SN definition. In total eight patients, 4/22 metastatic nodes were SNs while 18/22 were non-SNs.CONCLUSIONS: Sentinel node detection in MIBC is feasible also in NAC patients, regardless of pT stage. SNd played no role in nodal staging. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
653 | a Urinary bladder neoplasms | |
653 | a Neoadjuvant therapy | |
653 | a Cisplatin | |
653 | a Sentinel lymph node biopsy | |
653 | a Cystectomy | |
653 | a Immunotherapy | |
700 | 1 | a Johansson, Markusu Sundsvall Hosp, Dept Urol, Sundsvall, Sweden4 aut |
700 | 1 | a Alamdari, Farhoodu Vastmanland Hosp, Dept Urol, Vasteras, Sweden4 aut |
700 | 1 | a Sidiki, Alexanderu Lanssjukhuset Ryhov, Dept Urol, Jonkoping, Sweden4 aut |
700 | 1 | a Holmström, Bennyu Uppsala universitet,Urologkirurgi4 aut |
700 | 1 | a Hansson, Johan,d 1964-u Uppsala universitet,Centrum för klinisk forskning, Gävleborg4 aut0 (Swepub:uu)johan031 |
700 | 1 | a Vasko, Janosu Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, Umea, Sweden4 aut0 (Swepub:umu)jasvao04 |
700 | 1 | a Marits, Peru Karolinska Institutet4 aut |
700 | 1 | a Gabrielsson, Susanneu Karolinska Institutet4 aut |
700 | 1 | a Riklund, Katrineu Umeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden4 aut0 (Swepub:umu)kaah0001 |
700 | 1 | a Winqvist, Olau Karolinska Institutet4 aut |
700 | 1 | a Sherif, Amiru Umeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden4 aut0 (Swepub:umu)amsh0008 |
710 | 2 | a Umeå universitetb Urologi och andrologi4 org |
773 | 0 | t World journal of urologyd : Springer Science and Business Media LLCg 35:6, s. 921-927q 35:6<921-927x 0724-4983x 1433-8726 |
856 | 4 | u https://doi.org/10.1007/s00345-016-1952-xy Fulltext |
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856 | 4 | u https://link.springer.com/content/pdf/10.1007%2Fs00345-016-1952-x.pdf |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1250907/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127668 |
856 | 4 8 | u https://doi.org/10.1007/s00345-016-1952-x |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361224 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135959463 |
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