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No interactions bet...
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
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Scott, Robert A (author)
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Chu, Audrey Y (author)
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Grarup, Niels (author)
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show more...
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Manning, Alisa K (author)
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Hivert, Marie-France (author)
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- Shungin, Dmitry (author)
- Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Institutionen för odontologi,Medicin
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Tönjes, Anke (author)
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Yesupriya, Ajay (author)
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Barnes, Daniel (author)
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Bouatia-Naji, Nabila (author)
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Glazer, Nicole L (author)
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Jackson, Anne U (author)
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Kutalik, Zoltán (author)
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Lagou, Vasiliki (author)
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Marek, Diana (author)
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Rasmussen-Torvik, Laura J (author)
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Stringham, Heather M (author)
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Tanaka, Toshiko (author)
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Aadahl, Mette (author)
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Arking, Dan E (author)
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Bergmann, Sven (author)
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Boerwinkle, Eric (author)
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Bonnycastle, Lori L (author)
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Bornstein, Stefan R (author)
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Brunner, Eric (author)
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Bumpstead, Suzannah J (author)
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Brage, Soren (author)
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Carlson, Olga D (author)
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Chen, Han (author)
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Chen, Yii-Der Ida (author)
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Chines, Peter S (author)
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Collins, Francis S (author)
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Couper, David J (author)
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Dennison, Elaine M (author)
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Dowling, Nicole F (author)
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Egan, Josephine S (author)
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Ekelund, Ulf (author)
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Erdos, Michael R (author)
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Forouhi, Nita G (author)
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Fox, Caroline S (author)
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Goodarzi, Mark O (author)
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Grässler, Jürgen (author)
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Gustafsson, Stefan (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Hansen, Torben (author)
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Hingorani, Aroon (author)
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Holloway, John W (author)
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Hu, Frank B (author)
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Isomaa, Bo (author)
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Jameson, Karen A (author)
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- Johansson, Ingegerd (author)
- Umeå universitet,Kariologi
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- Jonsson, Anna (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Jørgensen, Torben (author)
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Kivimaki, Mika (author)
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Kovacs, Peter (author)
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Kumari, Meena (author)
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Kuusisto, Johanna (author)
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Laakso, Markku (author)
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Lecoeur, Cécile (author)
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Lévy-Marchal, Claire (author)
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Li, Guo (author)
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Loos, Ruth J F (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Marmot, Michael (author)
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Marques-Vidal, Pedro (author)
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Morken, Mario A (author)
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Müller, Gabriele (author)
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North, Kari E (author)
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Pankow, James S (author)
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Payne, Felicity (author)
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Prokopenko, Inga (author)
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Psaty, Bruce M (author)
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- Renström, Frida (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Rice, Ken (author)
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Rotter, Jerome I (author)
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Rybin, Denis (author)
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Sandholt, Camilla H (author)
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Sayer, Avan A (author)
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Shrader, Peter (author)
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Schwarz, Peter E H (author)
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Siscovick, David S (author)
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Stancáková, Alena (author)
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Stumvoll, Michael (author)
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Teslovich, Tanya M (author)
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Waeber, Gérard (author)
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Williams, Gordon H (author)
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Witte, Daniel R (author)
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Wood, Andrew R (author)
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Xie, Weijia (author)
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Boehnke, Michael (author)
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Cooper, Cyrus (author)
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Ferrucci, Luigi (author)
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Froguel, Philippe (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Kao, W H Linda (author)
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Vollenweider, Peter (author)
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Walker, Mark (author)
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Watanabe, Richard M (author)
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Pedersen, Oluf (author)
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Meigs, James B (author)
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- Ingelsson, Erik, 1975- (author)
- Karolinska Institutet
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Barroso, Inês (author)
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Florez, Jose C (author)
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- Franks, Paul (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology
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Dupuis, Josée (author)
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Wareham, Nicholas J (author)
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Langenberg, Claudia (author)
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(creator_code:org_t)
- 2012-04-13
- 2012
- English.
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In: Diabetes. - Alexandria, VA : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 61:5, s. 1291-1296
- Related links:
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https://diabetes.dia...
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show more...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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Diabetes
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
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Scott, Robert A
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Chu, Audrey Y
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Grarup, Niels
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Manning, Alisa K
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Hivert, Marie-Fr ...
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Shungin, Dmitry
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show more...
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Tönjes, Anke
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Yesupriya, Ajay
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Barnes, Daniel
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Bouatia-Naji, Na ...
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Glazer, Nicole L
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Jackson, Anne U
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Kutalik, Zoltán
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Lagou, Vasiliki
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Marek, Diana
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Rasmussen-Torvik ...
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Stringham, Heath ...
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Tanaka, Toshiko
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Aadahl, Mette
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Arking, Dan E
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Bergmann, Sven
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Boerwinkle, Eric
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Bonnycastle, Lor ...
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Bornstein, Stefa ...
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Brunner, Eric
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Bumpstead, Suzan ...
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Brage, Soren
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Carlson, Olga D
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Chen, Han
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Chen, Yii-Der Id ...
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Chines, Peter S
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Collins, Francis ...
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Couper, David J
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Dennison, Elaine ...
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Dowling, Nicole ...
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Egan, Josephine ...
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Ekelund, Ulf
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Erdos, Michael R
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Forouhi, Nita G
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Fox, Caroline S
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Goodarzi, Mark O
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Grässler, Jürgen
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Gustafsson, Stef ...
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Hallmans, Göran
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Hansen, Torben
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Hingorani, Aroon
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Holloway, John W
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Hu, Frank B
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Isomaa, Bo
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Jameson, Karen A
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Johansson, Ingeg ...
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Jonsson, Anna
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Jørgensen, Torbe ...
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Kivimaki, Mika
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Kovacs, Peter
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Kumari, Meena
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Kuusisto, Johann ...
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Laakso, Markku
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Lecoeur, Cécile
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Lévy-Marchal, Cl ...
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Li, Guo
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Loos, Ruth J F
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Lyssenko, Valeri ...
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Marmot, Michael
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Marques-Vidal, P ...
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Morken, Mario A
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Müller, Gabriele
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North, Kari E
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Pankow, James S
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Payne, Felicity
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Prokopenko, Inga
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Psaty, Bruce M
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Renström, Frida
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Rice, Ken
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Rotter, Jerome I
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Rybin, Denis
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Sandholt, Camill ...
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Sayer, Avan A
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Shrader, Peter
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Schwarz, Peter E ...
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Siscovick, David ...
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Stancáková, Alen ...
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Stumvoll, Michae ...
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Teslovich, Tanya ...
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Waeber, Gérard
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Williams, Gordon ...
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Witte, Daniel R
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Wood, Andrew R
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Xie, Weijia
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Boehnke, Michael
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Cooper, Cyrus
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Ferrucci, Luigi
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Froguel, Philipp ...
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Groop, Leif
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Kao, W H Linda
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Vollenweider, Pe ...
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Walker, Mark
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Watanabe, Richar ...
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Pedersen, Oluf
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Meigs, James B
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Ingelsson, Erik, ...
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Barroso, Inês
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Florez, Jose C
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Franks, Paul
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Dupuis, Josée
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Wareham, Nichola ...
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Langenberg, Clau ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Uppsala University
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Lund University
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Umeå University
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Karolinska Institutet