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Symptom Diaries of ...
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Strosberg, Jonathan R.H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
(författare)
Symptom Diaries of Patients with Midgut Neuroendocrine Tumors Treated with 177Lu-DOTATATE
- Artikel/kapitelEngelska2021
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2021-03-26
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Society of Nuclear Medicine,2021
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-462222
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-462222URI
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https://doi.org/10.2967/jnumed.120.258897DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Title in Web of Science: Symptom Diaries of Patients with Midgut Neuroendocrine Tumors Treated with Lu-177-DOTATATE
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We report the impact of 177Lu-DOTATATE treatment on abdominal pain, diarrhea, and flushing, symptoms that patients with advanced midgut neuroendocrine tumors often find burdensome.Methods: All patients enrolled in the international randomized phase 3 Neuroendocrine Tumors Therapy (NETTER-1) trial (177Lu-DOTATATE plus standard-dose octreotide long-acting repeatable [LAR], n = 117; high-dose octreotide LAR, n = 114) were asked to record the occurrence of predefined symptoms in a daily diary. Change from baseline in symptom scores (mean number of days with a symptom) was analyzed using a mixed model for repeated measures.Results: Patients (intent-to-treat) who received 177Lu-DOTATATE experienced a significantly greater decline from baseline in symptom scores than patients who received high-dose octreotide LAR. For 177Lu-DOTATATE, the mean decline in days with abdominal pain, diarrhea, and flushing was 4.10, 4.55, and 4.52 d per 4 wk, respectively, compared with 0.99, 1.44, and 2.54 d for high-dose octreotide LAR. The mean differences were 3.11 d (95% CI, 1.35–4.88; P = 0.0007) for abdominal pain, 3.11 d (1.18–5.04; P = 0.0017) for diarrhea, and 1.98 d (0.08–3.88; P = 0.0413) for flushing, favoring 177Lu-DOTATATE. A positive repeated-measures correlation was found between diary-recorded symptom scores and questionnaire-recorded pain, diarrhea, and flushing.Conclusion: In addition to efficacy and quality-of-life benefits, symptom diaries from NETTER-1 demonstrated that treatment with 177Lu-DOTATATE was associated with statistically significant reductions in abdominal pain, diarrhea, and flushing, constituting the core symptoms of patients with progressive midgut neuroendocrine tumors, compared with high-dose octreotide LAR, supporting a beneficial effect of 177Lu-DOTATATE on health-related quality of life.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Srirajaskanthan, RajaventhanKings Coll Hosp London, Dept Gastroenterol, Neuroendocrine Tumour Unit, London, England.
(författare)
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El-Haddad, GhassanH Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
(författare)
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Wolin, Edward M.Tish Canc Inst Mt Sinai, Ctr Carcinoid & Neuroendocrine Tumors, New York, NY USA.
(författare)
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Chasen, Beth R.Univ Texas MD Anderson Canc Ctr, Dept Nucl Med, Div Diagnost Imaging, Houston, TX 77030 USA.
(författare)
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Kulke, Matthew H.Boston Univ, Sect Hematol & Med Oncol, Boston, MA 02215 USA.;Boston Med Ctr, Boston, MA 02215 USA.
(författare)
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Bushnell, David L.Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA.
(författare)
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Caplin, Martyn E.Royal Free Hosp, Neuroendocrine Tumour Unit, London, England.
(författare)
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Baum, Richard P.DKD Helios Clin, Curanosticum Wiesbaden Frankfurt, Wiesbaden, Germany.
(författare)
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Hendifar, Andrew E.Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA.
(författare)
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Öberg, Kjell,1946-Uppsala universitet,Endokrin tumörbiologi(Swepub:uu)kjellob
(författare)
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Ruszniewski, PhilippeDiv Gastroenterol & Pancreatol, Hop Beaujon, Clichy, France.
(författare)
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Santoro, PaolaAdv Accelerator Applicat, Millburn, NJ USA.
(författare)
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Broberg, PerAdv Accelerator Applicat, Geneva, Switzerland.
(författare)
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Leeuwenkamp, Oscar R.Adv Accelerator Applicat, Geneva, Switzerland.
(författare)
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Krenning, Eric P.Erasmus MC, Cyclotron Rotterdam BV, Rotterdam, Netherlands.
(författare)
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H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.Kings Coll Hosp London, Dept Gastroenterol, Neuroendocrine Tumour Unit, London, England.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Nuclear Medicine: Society of Nuclear Medicine62:12, s. 1712-17180161-55051535-56672159-662X
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