NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium

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Sökning: (WFRF:(Struchalin Maksim)) pers:(Campbell Harry) > (2009) > NRXN3 is a novel lo...

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Fältnamn	Indikatorer	Metadata
000		05026naa a2201021 4500
001		oai:DiVA.org:uu-124313
003		SwePub
008		100503s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1243132 URI
024	7	a https://doi.org/10.1371/journal.pgen.10005392 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Heard-Costa, Nancy L4 aut
245	1 0	a NRXN3 is a novel locus for waist circumference :b a genome-wide association study from the CHARGE Consortium
264		c 2009-06-26
264	1	b Public Library of Science (PLoS),c 2009
338		a print2 rdacarrier
520		a Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist circumference (WC). In total, three loci reached genome-wide significance. In stage 1, 31,373 individuals of Caucasian descent from eight cohort studies confirmed the role of FTO and MC4R and identified one novel locus associated with WC in the neurexin 3 gene [NRXN3 (rs10146997, p = 6.4×10−7)]. The association with NRXN3 was confirmed in stage 2 by combining stage 1 results with those from 38,641 participants in the GIANT consortium (p = 0.009 in GIANT only, p = 5.3×10−8 for combined analysis, n = 70,014). Mean WC increase per copy of the G allele was 0.0498 z-score units (0.65 cm). This SNP was also associated with body mass index (BMI) [p = 7.4×10−6, 0.024 z-score units (0.10 kg/m2) per copy of the G allele] and the risk of obesity (odds ratio 1.13, 95% CI 1.07–1.19; p = 3.2×10−5 per copy of the G allele). The NRXN3 gene has been previously implicated in addiction and reward behavior, lending further evidence that common forms of obesity may be a central nervous system-mediated disorder. Our findings establish that common variants in NRXN3 are associated with WC, BMI, and obesity.
653		a MEDICINE
653		a MEDICIN
700	1	a Zillikens, M Carola4 aut
700	1	a Monda, Keri L4 aut
700	1	a Johansson, Åsau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)asjoh108
700	1	a Harris, Tamara B4 aut
700	1	a Fu, Mao4 aut
700	1	a Haritunians, Talin4 aut
700	1	a Feitosa, Mary F4 aut
700	1	a Aspelund, Thor4 aut
700	1	a Eiriksdottir, Gudny4 aut
700	1	a Garcia, Melissa4 aut
700	1	a Launer, Lenore J4 aut
700	1	a Smith, Albert V4 aut
700	1	a Mitchell, Braxton D4 aut
700	1	a McArdle, Patrick F4 aut
700	1	a Shuldiner, Alan R4 aut
700	1	a Bielinski, Suzette J4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Brancati, Fred4 aut
700	1	a Demerath, Ellen W4 aut
700	1	a Pankow, James S4 aut
700	1	a Arnold, Alice M4 aut
700	1	a Chen, Yii-Der Ida4 aut
700	1	a Glazer, Nicole L4 aut
700	1	a McKnight, Barbara4 aut
700	1	a Psaty, Bruce M4 aut
700	1	a Rotter, Jerome I4 aut
700	1	a Amin, Najaf4 aut
700	1	a Campbell, Harry4 aut
700	1	a Gyllensten, Ulfu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)ulfgyll
700	1	a Pattaro, Cristian4 aut
700	1	a Pramstaller, Peter P4 aut
700	1	a Rudan, Igor4 aut
700	1	a Struchalin, Maksim4 aut
700	1	a Vitart, Veronique4 aut
700	1	a Gao, Xiaoyi4 aut
700	1	a Kraja, Aldi4 aut
700	1	a Province, Michael A4 aut
700	1	a Zhang, Qunyuan4 aut
700	1	a Atwood, Larry D4 aut
700	1	a Dupuis, Josée4 aut
700	1	a Hirschhorn, Joel N4 aut
700	1	a Jaquish, Cashell E4 aut
700	1	a O'Donnell, Christopher J4 aut
700	1	a Vasan, Ramachandran S4 aut
700	1	a White, Charles C4 aut
700	1	a Aulchenko, Yurii S4 aut
700	1	a Estrada, Karol4 aut
700	1	a Hofman, Albert4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a Witteman, Jacqueline C M4 aut
700	1	a Oostra, Ben A4 aut
700	1	a Kaplan, Robert C4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a O'Connell, Jeffrey R4 aut
700	1	a Borecki, Ingrid B4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Cupples, L Adrienne4 aut
700	1	a Fox, Caroline S4 aut
700	1	a North, Kari E4 aut
710	2	a Uppsala universitetb Institutionen för genetik och patologi4 org
773	0	t PLoS geneticsd : Public Library of Science (PLoS)g 5:6, s. e1000539-q 5:6<e1000539-x 1553-7404
856	4	u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000539&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124313
856	4 8	u https://doi.org/10.1371/journal.pgen.1000539

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Av författaren/redakt...: Heard-Costa, Nan ...; Zillikens, M Car ...; Monda, Keri L; Johansson, Åsa; Harris, Tamara B; Fu, Mao; visa fler...; Haritunians, Tal ...; Feitosa, Mary F; Aspelund, Thor; Eiriksdottir, Gu ...; Garcia, Melissa; Launer, Lenore J; Smith, Albert V; Mitchell, Braxto ...; McArdle, Patrick ...; Shuldiner, Alan ...; Bielinski, Suzet ...; Boerwinkle, Eric; Brancati, Fred; Demerath, Ellen ...; Pankow, James S; Arnold, Alice M; Chen, Yii-Der Id ...; Glazer, Nicole L; McKnight, Barbar ...; Psaty, Bruce M; Rotter, Jerome I; Amin, Najaf; Campbell, Harry; Gyllensten, Ulf; Pattaro, Cristia ...; Pramstaller, Pet ...; Rudan, Igor; Struchalin, Maks ...; Vitart, Veroniqu ...; Gao, Xiaoyi; Kraja, Aldi; Province, Michae ...; Zhang, Qunyuan; Atwood, Larry D; Dupuis, Josée; Hirschhorn, Joel ...; Jaquish, Cashell ...; O'Donnell, Chris ...; Vasan, Ramachand ...; White, Charles C; Aulchenko, Yurii ...; Estrada, Karol; Hofman, Albert; Rivadeneira, Fer ...; Uitterlinden, An ...; Witteman, Jacque ...; Oostra, Ben A; Kaplan, Robert C; Gudnason, Vilmun ...; O'Connell, Jeffr ...; Borecki, Ingrid ...; van Duijn, Corne ...; Cupples, L Adrie ...; Fox, Caroline S; North, Kari E; visa färre...

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