(WFRF:(Svanes Cecilie)) pers:(Real Francisco Gomez)
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Lung function, respiratory symptoms, and the menopausal transition
- Real, Francisco Gómez (author)
- Svanes, Cecilie (author)
- Omenaas, Ernst Reidar (author)
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- Antò, Josep Maria (author)
- Plana, Estel (author)
- Jarvis, Deborah (author)
- Neukirch, Françoise (author)
- Zemp, Elisabeth (author)
- Dratva, Julia (author)
- Wjst, Matthias (author)
- Svanes, Knut (author)
- Leynaert, Bénédicte (author)
- Sunyer, Jordi (author)
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- (creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
- In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 121:1, s. 72-80.e3
- Journal article (peer-reviewed)
Abstract
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- BACKGROUND: There is limited information on potential changes in respiratory health when women enter the menopausal transition. OBJECTIVE: We sought to investigate whether the menopausal transition is related to lung function and asthma and whether body mass index (BMI) modifies associations. METHODS: Four thousand two hundred fifty-nine women from 21 centers (ECRHS II, 2002) responded to a questionnaire concerning women's health. Women aged 45 to 56 years not using exogenous sex hormones (n = 1274) were included in the present analysis. Lung function measurements (n = 1120) and serum markers of hormonal status (follicle-stimulating hormone, luteinizing hormone, and estradiol; n = 710) were available. Logistic and linear regression analyses were adjusted for BMI, age, years of education, smoking status, center, and height. RESULTS: Women not menstruating for the last 6 months (n = 432, 34%) had significantly lower FEV(1) values (-120 mL [95% CI, -177 to -63]), lower forced vital capacity values (-115 mL [95% CI, -181 to -50]), and more respiratory symptoms (odds ratio [OR], 1.82 [95% CI, 1.27-2.61]) than those menstruating regularly. Results were similar when restricting analyses to those who never smoked. Associations were significantly stronger in women with BMIs of less than 23 kg/m(2) (respiratory symptoms: OR, 4.07 [95% CI, 1.88-8.80]; FEV(1) adjusted difference: -166 [95% CI, -263 to -70]) than in women with BMIs of 23 to 28 kg/m(2) (respiratory symptoms: OR, 1.10 [95% CI, 0.61-1.97], P(interaction): .04; FEV(1) adjusted difference, -54 [95% CI, -151 to 43], P(interaction) = .06). CONCLUSIONS: Menopause is associated with lower lung function and more respiratory symptoms, especially among lean women.
Keyword
- Asthma/epidemiology
- Body Mass Index
- Female
- Forced Expiratory Volume
- Humans
- Hypersensitivity/epidemiology/etiology
- Menopause
- Middle Aged
- Respiration Disorders/epidemiology/etiology
- Respiratory Function Tests
- Respiratory Physiology
- Vital Capacity
- Women's Health
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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