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Acyl-CoA-binding pr...
Acyl-CoA-binding protein (ACBP) : a phylogenetically conserved appetite stimulator
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Charmpilas, Nikolaos (author)
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Ruckenstuhl, Christoph (author)
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Sica, Valentina (author)
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- Büttner, Sabrina (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria
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- Habernig, Lukas (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Dichtinger, Silvia (author)
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Madeo, Frank (author)
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Tavernarakis, Nektarios (author)
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Bravo-San Pedro, José M. (author)
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Kroemer, Guido (author)
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(creator_code:org_t)
- 2020-01-06
- 2020
- English.
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In: Cell Death and Disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 11:1
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https://doi.org/10.1...
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https://www.nature.c...
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Abstract
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- Recently, we reported that, in mice, hunger causes the autophagy-dependent release of a protein called acyl-CoA-binding protein or diazepam binding inhibitor (ACBP/DBI) from cells, resulting in an increase in plasma ACBP concentrations. Administration of extra ACBP is orexigenic and obesogenic, while its neutralization is anorexigenic in mice, suggesting that ACBP is a major stimulator of appetite and lipo-anabolism. Accordingly, obese persons have higher circulating ACBP levels than lean individuals, and anorexia nervosa is associated with subnormal ACBP plasma concentrations. Here, we investigated whether ACBP might play a phylogenetically conserved role in appetite stimulation. We found that extracellular ACBP favors sporulation in Saccharomyces cerevisiae, knowing that sporulation is a strategy for yeast to seek new food sources. Moreover, in the nematode Caenorhabditis elegans, ACBP increased the ingestion of bacteria as well as the frequency pharyngeal pumping. These observations indicate that ACBP has a phylogenetically ancient role as a 'hunger factor' that favors food intake.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Charmpilas, Niko ...
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Ruckenstuhl, Chr ...
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Sica, Valentina
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Büttner, Sabrina
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Habernig, Lukas
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Dichtinger, Silv ...
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show more...
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Madeo, Frank
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Tavernarakis, Ne ...
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Bravo-San Pedro, ...
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Kroemer, Guido
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Cell Death and D ...
- By the university
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Stockholm University
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Karolinska Institutet