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Combination chemoth...
Combination chemotherapy in advanced adrenocortical carcinoma
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Fassnacht, Martin (author)
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Terzolo, Massimo (author)
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Allolio, Bruno (author)
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show more...
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Baudin, Eric (author)
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Haak, Harm (author)
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Berruti, Alfredo (author)
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- Welin, Staffan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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Schade-Brittinger, Carmen (author)
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Lacroix, André (author)
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Jarzab, Barbara (author)
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Sorbye, Halfdan (author)
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Torpy, David J (author)
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Stepan, Vinzenz (author)
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Schteingart, David E (author)
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Arlt, Wiebke (author)
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Kroiss, Matthias (author)
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Leboulleux, Sophie (author)
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Sperone, Paola (author)
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- Sundin, Anders (author)
- Karolinska Institutet,Uppsala universitet,Enheten för radiologi
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Hermsen, Ilse (author)
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Hahner, Stefanie (author)
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Willenberg, Holger S (author)
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Tabarin, Antoine (author)
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Quinkler, Marcus (author)
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de la Fouchardière, Christelle (author)
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Schlumberger, Martin (author)
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Mantero, Franco (author)
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Weismann, Dirk (author)
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Beuschlein, Felix (author)
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Gelderblom, Hans (author)
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Wilmink, Hanneke (author)
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Sender, Monica (author)
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Edgerly, Maureen (author)
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Kenn, Werner (author)
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Fojo, Tito (author)
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Müller, Hans-Helge (author)
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- Skogseid, Britt (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrin tumörbiologi
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 366:23, s. 2189-2197
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- BACKGROUND:Adrenocortical carcinoma is a rare cancer that has a poor response to cytotoxic treatment.METHODS:We randomly assigned 304 patients with advanced adrenocortical carcinoma to receive mitotane plus either a combination of etoposide (100 mg per square meter of body-surface area on days 2 to 4), doxorubicin (40 mg per square meter on day 1), and cisplatin (40 mg per square meter on days 3 and 4) (EDP) every 4 weeks or streptozocin (streptozotocin) (1 g on days 1 to 5 in cycle 1; 2 g on day 1 in subsequent cycles) every 3 weeks. Patients with disease progression received the alternative regimen as second-line therapy. The primary end point was overall survival.RESULTS:For first-line therapy, patients in the EDP-mitotane group had a significantly higher response rate than those in the streptozocin-mitotane group (23.2% vs. 9.2%, P<0.001) and longer median progression-free survival (5.0 months vs. 2.1 months; hazard ratio, 0.55; 95% confidence interval [CI], 0.43 to 0.69; P<0.001); there was no significant between-group difference in overall survival (14.8 months and 12.0 months, respectively; hazard ratio, 0.79; 95% CI, 0.61 to 1.02; P=0.07). Among the 185 patients who received the alternative regimen as second-line therapy, the median duration of progression-free survival was 5.6 months in the EDP-mitotane group and 2.2 months in the streptozocin-mitotane group. Patients who did not receive the alternative second-line therapy had better overall survival with first-line EDP plus mitotane (17.1 month) than with streptozocin plus mitotane (4.7 months). Rates of serious adverse events did not differ significantly between treatments.CONCLUSIONS:Rates of response and progression-free survival were significantly better with EDP plus mitotane than with streptozocin plus mitotane as first-line therapy, with similar rates of toxic events, although there was no significant difference in overall survival.
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- By the author/editor
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Fassnacht, Marti ...
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Terzolo, Massimo
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Allolio, Bruno
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Baudin, Eric
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Haak, Harm
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Berruti, Alfredo
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show more...
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Welin, Staffan
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Schade-Brittinge ...
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Lacroix, André
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Jarzab, Barbara
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Sorbye, Halfdan
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Torpy, David J
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Stepan, Vinzenz
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Schteingart, Dav ...
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Arlt, Wiebke
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Kroiss, Matthias
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Leboulleux, Soph ...
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Sperone, Paola
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Sundin, Anders
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Hermsen, Ilse
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Hahner, Stefanie
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Willenberg, Holg ...
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Tabarin, Antoine
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Quinkler, Marcus
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de la Fouchardiè ...
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Schlumberger, Ma ...
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Mantero, Franco
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Weismann, Dirk
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Beuschlein, Feli ...
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Gelderblom, Hans
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Wilmink, Hanneke
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Sender, Monica
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Edgerly, Maureen
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Kenn, Werner
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Fojo, Tito
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Müller, Hans-Hel ...
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Skogseid, Britt
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show less...
- Articles in the publication
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New England Jour ...
- By the university
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Uppsala University
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Karolinska Institutet