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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08472naa a2202005 4500 | |
| 001 | oai:lup.lub.lu.se:f908378b-b855-4501-b82d-2d917663712c | |
| 003 | SwePub | |
| 008 | 160401s2007 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:1953048 | |
| 024 | 7 | a https://lup.lub.lu.se/record/6672932 URI |
| 024 | 7 | a https://doi.org/10.1056/NEJMoa0617412 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19530482 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Villa, Luisa L.4 aut |
| 245 | 1 0 | a Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions |
| 264 | 1 | c 2007 |
| 520 | a BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 700 | 1 | a Perez, Gonzalo4 aut |
| 700 | 1 | a Kjaer, Susanne K.4 aut |
| 700 | 1 | a Paavonen, Jorma4 aut |
| 700 | 1 | a Lehtinen, Matti4 aut |
| 700 | 1 | a Munoz, Nubia4 aut |
| 700 | 1 | a Sigurdsson, Kristjan4 aut |
| 700 | 1 | a Hernandez-Avila, Mauricio4 aut |
| 700 | 1 | a Skjeldestad, Finn Egil4 aut |
| 700 | 1 | a Thoresen, Steinar4 aut |
| 700 | 1 | a Garcia, Patricia4 aut |
| 700 | 1 | a Majewski, Slawomir4 aut |
| 700 | 1 | a Dillner, Joakimu Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-jdi |
| 700 | 1 | a Olsson, Sven-Ericu Karolinska Institutet4 aut |
| 700 | 1 | a Tay, Eng Hseon4 aut |
| 700 | 1 | a Bosch, F. Xavier4 aut |
| 700 | 1 | a Ault, Kevin A.4 aut |
| 700 | 1 | a Brown, Darron R.4 aut |
| 700 | 1 | a Ferris, Daron G.4 aut |
| 700 | 1 | a Koutsky, Laura A.4 aut |
| 700 | 1 | a Kurman, Robert J.4 aut |
| 700 | 1 | a Myers, Evan R.4 aut |
| 700 | 1 | a Barr, Eliav4 aut |
| 700 | 1 | a Boslego, John4 aut |
| 700 | 1 | a Bryan, Janine4 aut |
| 700 | 1 | a Esser, Mark T.4 aut |
| 700 | 1 | a Gause, Christine K.4 aut |
| 700 | 1 | a Hesley, Teresa M.4 aut |
| 700 | 1 | a Lupinacci, Lisa C.4 aut |
| 700 | 1 | a Sings, Heather L.4 aut |
| 700 | 1 | a Taddeo, Frank J.4 aut |
| 700 | 1 | a Thornton, Annemarie R.4 aut |
| 700 | 1 | a Boulos, M.4 aut |
| 700 | 1 | a Cox, J. T.4 aut |
| 700 | 1 | a Langmark, F.4 aut |
| 700 | 1 | a Modlin, J.4 aut |
| 700 | 1 | a Munoz, A.4 aut |
| 700 | 1 | a Odlind, V.4 aut |
| 700 | 1 | a Wilkinson, E.4 aut |
| 700 | 1 | a Ferenczy, A.4 aut |
| 700 | 1 | a Kurman, R.4 aut |
| 700 | 1 | a Ronett, B.4 aut |
| 700 | 1 | a Stoler, M.4 aut |
| 700 | 1 | a Andreoni, G.4 aut |
| 700 | 1 | a Bahamondes, L.4 aut |
| 700 | 1 | a Camargos, A.4 aut |
| 700 | 1 | a Costa, R.4 aut |
| 700 | 1 | a De Andrade, R.4 aut |
| 700 | 1 | a Fedrizzi, E.4 aut |
| 700 | 1 | a Ferriani, R.4 aut |
| 700 | 1 | a Goncalves, M.4 aut |
| 700 | 1 | a Laginha, F.4 aut |
| 700 | 1 | a Mendonca, J.4 aut |
| 700 | 1 | a Moreira, E., Jr.4 aut |
| 700 | 1 | a Nonnenmacher, B.4 aut |
| 700 | 1 | a Taborda, W.4 aut |
| 700 | 1 | a Zanetta, D.4 aut |
| 700 | 1 | a Ardila, J.4 aut |
| 700 | 1 | a Balcazar, N.4 aut |
| 700 | 1 | a Maldonado, I.4 aut |
| 700 | 1 | a Revollo, F.4 aut |
| 700 | 1 | a Ruiz, A.4 aut |
| 700 | 1 | a Andersen, E. S.4 aut |
| 700 | 1 | a Djursing, H.4 aut |
| 700 | 1 | a Hansen, T.4 aut |
| 700 | 1 | a Jorgensen, J. J.4 aut |
| 700 | 1 | a Nilas, L.4 aut |
| 700 | 1 | a Ottesen, B.4 aut |
| 700 | 1 | a Petersen, L. K.4 aut |
| 700 | 1 | a Thomsen, S. G.4 aut |
| 700 | 1 | a Toftager-Larsen, K.4 aut |
| 700 | 1 | a Apter, D.4 aut |
| 700 | 1 | a Kekki, M.4 aut |
| 700 | 1 | a Kuortti, M.4 aut |
| 700 | 1 | a Lahti, L.4 aut |
| 700 | 1 | a Lindroos, Y.4 aut |
| 700 | 1 | a Lunnas, T.4 aut |
| 700 | 1 | a Paavonen, J.4 aut |
| 700 | 1 | a Palmroth, J.4 aut |
| 700 | 1 | a Sigurdsson, K.4 aut |
| 700 | 1 | a Lazcano, E.4 aut |
| 700 | 1 | a Zertuche, J.4 aut |
| 700 | 1 | a Dalaker, K.4 aut |
| 700 | 1 | a Eriksen, B.4 aut |
| 700 | 1 | a Erno, L. E.4 aut |
| 700 | 1 | a Fiane, B.4 aut |
| 700 | 1 | a Hesla, K.4 aut |
| 700 | 1 | a Isachsen, M. Myhre4 aut |
| 700 | 1 | a Iversen, O. E.4 aut |
| 700 | 1 | a Kasin, K.4 aut |
| 700 | 1 | a Kristoffersen, M.4 aut |
| 700 | 1 | a Lunde, T.4 aut |
| 700 | 1 | a Nordmark, P. T.4 aut |
| 700 | 1 | a Nygaard, T.4 aut |
| 700 | 1 | a Onsrud, M.4 aut |
| 700 | 1 | a Riis-Johannessen, G.4 aut |
| 700 | 1 | a Schiotz, H.4 aut |
| 700 | 1 | a Skjeldestad, F. E.4 aut |
| 700 | 1 | a Sundhagen, H.4 aut |
| 700 | 1 | a Sviggum, O.4 aut |
| 700 | 1 | a Trosterud, K. A.4 aut |
| 700 | 1 | a Garcia, P.4 aut |
| 700 | 1 | a Penny, M.4 aut |
| 700 | 1 | a Vivar, A.4 aut |
| 700 | 1 | a Basta, A.4 aut |
| 700 | 1 | a Czajkowski, K.4 aut |
| 700 | 1 | a Knapp, P.4 aut |
| 700 | 1 | a Spaczynski, M.4 aut |
| 700 | 1 | a Barnes, R.4 aut |
| 700 | 1 | a Tay, E. H.4 aut |
| 700 | 1 | a Elfgren, K.4 aut |
| 700 | 1 | a Hardmeier, E.4 aut |
| 700 | 1 | a Hellsten, C.4 aut |
| 700 | 1 | a Hofte, C.4 aut |
| 700 | 1 | a Jensen, P.4 aut |
| 700 | 1 | a Johannisson, G.4 aut |
| 700 | 1 | a Loewhagen, G. -B.4 aut |
| 700 | 1 | a Olsson, S. -E.4 aut |
| 700 | 1 | a Steinwall, M.4 aut |
| 700 | 1 | a Tamsen, L.4 aut |
| 700 | 1 | a Varnauskas, T.4 aut |
| 700 | 1 | a Wikstroem, A.u Karolinska Institutet4 aut |
| 700 | 1 | a Crawford, G.4 aut |
| 700 | 1 | a Allen, B.4 aut |
| 700 | 1 | a Ault, K.4 aut |
| 700 | 1 | a Brown, D.4 aut |
| 700 | 1 | a Edwards, R.4 aut |
| 700 | 1 | a Comerci, J.4 aut |
| 700 | 1 | a Giuliano, A.4 aut |
| 700 | 1 | a Greer, S.4 aut |
| 700 | 1 | a Hatch, K.4 aut |
| 700 | 1 | a Kriesel, J.4 aut |
| 700 | 1 | a Lalezari, J.4 aut |
| 700 | 1 | a Partridge, E.4 aut |
| 700 | 1 | a Sperling, R.4 aut |
| 700 | 1 | a Spruance, S.4 aut |
| 700 | 1 | a Stapleton, J.4 aut |
| 700 | 1 | a Wright, P.4 aut |
| 700 | 1 | a Zedler, P.4 aut |
| 700 | 1 | a McCarroll, K.4 aut |
| 700 | 1 | a Zhang, L.4 aut |
| 700 | 1 | a Zhou, H.4 aut |
| 710 | 2 | a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t New England Journal of Medicineg 356:19, s. 1915-1927q 356:19<1915-1927x 0028-4793x 1533-4406 |
| 856 | 4 | u http://dx.doi.org/10.1056/NEJMoa061741y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/667293 |
| 856 | 4 8 | u https://doi.org/10.1056/NEJMoa061741 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1953048 |
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- Tay, Eng Hseon
- Bosch, F. Xavier
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- Brown, Darron R.
- Ferris, Daron G.
- Koutsky, Laura A ...
- Kurman, Robert J ...
- Myers, Evan R.
- Barr, Eliav
- Boslego, John
- Bryan, Janine
- Esser, Mark T.
- Gause, Christine ...
- Hesley, Teresa M ...
- Lupinacci, Lisa ...
- Sings, Heather L ...
- Taddeo, Frank J.
- Thornton, Annema ...
- Boulos, M.
- Cox, J. T.
- Langmark, F.
- Modlin, J.
- Munoz, A.
- Odlind, V.
- Wilkinson, E.
- Ferenczy, A.
- Kurman, R.
- Ronett, B.
- Stoler, M.
- Andreoni, G.
- Bahamondes, L.
- Camargos, A.
- Costa, R.
- De Andrade, R.
- Fedrizzi, E.
- Ferriani, R.
- Goncalves, M.
- Laginha, F.
- Mendonca, J.
- Moreira, E., Jr.
- Nonnenmacher, B.
- Taborda, W.
- Zanetta, D.
- Ardila, J.
- Balcazar, N.
- Maldonado, I.
- Revollo, F.
- Ruiz, A.
- Andersen, E. S.
- Djursing, H.
- Hansen, T.
- Jorgensen, J. J.
- Nilas, L.
- Ottesen, B.
- Petersen, L. K.
- Thomsen, S. G.
- Toftager-Larsen, ...
- Apter, D.
- Kekki, M.
- Kuortti, M.
- Lahti, L.
- Lindroos, Y.
- Lunnas, T.
- Paavonen, J.
- Palmroth, J.
- Sigurdsson, K.
- Lazcano, E.
- Zertuche, J.
- Dalaker, K.
- Eriksen, B.
- Erno, L. E.
- Fiane, B.
- Hesla, K.
- Isachsen, M. Myh ...
- Iversen, O. E.
- Kasin, K.
- Kristoffersen, M ...
- Lunde, T.
- Nordmark, P. T.
- Nygaard, T.
- Onsrud, M.
- Riis-Johannessen ...
- Schiotz, H.
- Skjeldestad, F. ...
- Sundhagen, H.
- Sviggum, O.
- Trosterud, K. A.
- Garcia, P.
- Penny, M.
- Vivar, A.
- Basta, A.
- Czajkowski, K.
- Knapp, P.
- Spaczynski, M.
- Barnes, R.
- Tay, E. H.
- Elfgren, K.
- Hardmeier, E.
- Hellsten, C.
- Hofte, C.
- Jensen, P.
- Johannisson, G.
- Loewhagen, G. -B ...
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- Steinwall, M.
- Tamsen, L.
- Varnauskas, T.
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- Ault, K.
- Brown, D.
- Edwards, R.
- Comerci, J.
- Giuliano, A.
- Greer, S.
- Hatch, K.
- Kriesel, J.
- Lalezari, J.
- Partridge, E.
- Sperling, R.
- Spruance, S.
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- Wright, P.
- Zedler, P.
- McCarroll, K.
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