Sökning: (WFRF:(Tsuang Debby)) > (2022) > Chronic neuropsychi...
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000 | 09650naa a2201417 4500 | |
001 | oai:gup.ub.gu.se/322192 | |
003 | SwePub | |
008 | 240528s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3221922 URI |
024 | 7 | a https://doi.org/10.1002/trc2.123482 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a de Erausquin, Gabriel A4 aut |
245 | 1 0 | a Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium. |
264 | c 2022-09-22 | |
264 | 1 | b Wiley,c 2022 |
520 | a Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term.This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions.Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe.The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection.The following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD)The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS-CoV-2 triggers ADRD-like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility.The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under-represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long-term consequences, and trends in cognitive aging, ADRD, and vascular disease.We provide a framework for current and future studies to be carried out within the Consortium. and offers a "green paper" to the research community with a very broad, global base of support, on tools suitable for low- and middle-income countries aimed to compare and combine future longitudinal data on the topic.The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID-19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high-quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Snyder, Heather4 aut |
700 | 1 | a Brugha, Traolach S4 aut |
700 | 1 | a Seshadri, Sudha4 aut |
700 | 1 | a Carrillo, Maria4 aut |
700 | 1 | a Sagar, Rajesh4 aut |
700 | 1 | a Huang, Yueqin4 aut |
700 | 1 | a Newton, Charles4 aut |
700 | 1 | a Tartaglia, Carmela4 aut |
700 | 1 | a Teunissen, Charlotte4 aut |
700 | 1 | a Håkanson, Krister4 aut |
700 | 1 | a Akinyemi, Rufus4 aut |
700 | 1 | a Prasad, Kameshwar4 aut |
700 | 1 | a D'Avossa, Giovanni4 aut |
700 | 1 | a Gonzalez-Aleman, Gabriela4 aut |
700 | 1 | a Hosseini, Akram4 aut |
700 | 1 | a Vavougios, George D4 aut |
700 | 1 | a Sachdev, Perminder4 aut |
700 | 1 | a Bankart, John4 aut |
700 | 1 | a Mors, Niels Peter Ole4 aut |
700 | 1 | a Lipton, Richard4 aut |
700 | 1 | a Katz, Mindy4 aut |
700 | 1 | a Fox, Peter T4 aut |
700 | 1 | a Katshu, Mohammad Zia4 aut |
700 | 1 | a Iyengar, M Sriram4 aut |
700 | 1 | a Weinstein, Galit4 aut |
700 | 1 | a Sohrabi, Hamid R4 aut |
700 | 1 | a Jenkins, Rachel4 aut |
700 | 1 | a Stein, Dan J4 aut |
700 | 1 | a Hugon, Jacques4 aut |
700 | 1 | a Mavreas, Venetsanos4 aut |
700 | 1 | a Blangero, John4 aut |
700 | 1 | a Cruchaga, Carlos4 aut |
700 | 1 | a Krishna, Murali4 aut |
700 | 1 | a Wadoo, Ovais4 aut |
700 | 1 | a Becerra, Rodrigo4 aut |
700 | 1 | a Zwir, Igor4 aut |
700 | 1 | a Longstreth, William T4 aut |
700 | 1 | a Kroenenberg, Golo4 aut |
700 | 1 | a Edison, Paul4 aut |
700 | 1 | a Mukaetova-Ladinska, Elizabeta4 aut |
700 | 1 | a Staufenberg, Ekkehart4 aut |
700 | 1 | a Figueredo-Aguiar, Mariana4 aut |
700 | 1 | a Yécora, Agustín4 aut |
700 | 1 | a Vaca, Fabiana4 aut |
700 | 1 | a Zamponi, Hernan P4 aut |
700 | 1 | a Re, Vincenzina Lo4 aut |
700 | 1 | a Majid, Abdul4 aut |
700 | 1 | a Sundarakumar, Jonas4 aut |
700 | 1 | a Gonzalez, Hector M4 aut |
700 | 1 | a Geerlings, Mirjam I4 aut |
700 | 1 | a Skoog, Ingmar,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)4 aut0 (Swepub:gu)xskooi |
700 | 1 | a Salmoiraghi, Alberto4 aut |
700 | 1 | a Boneschi, Filippo Martinelli4 aut |
700 | 1 | a Patel, Vibuthi N4 aut |
700 | 1 | a Santos, Juan M4 aut |
700 | 1 | a Arroyo, Guillermo Rivera4 aut |
700 | 1 | a Moreno, Antonio Caballero4 aut |
700 | 1 | a Felix, Pascal4 aut |
700 | 1 | a Gallo, Carla4 aut |
700 | 1 | a Arai, Hidenori4 aut |
700 | 1 | a Yamada, Masahito4 aut |
700 | 1 | a Iwatsubo, Takeshi4 aut |
700 | 1 | a Sharma, Malveeka4 aut |
700 | 1 | a Chakraborty, Nandini4 aut |
700 | 1 | a Ferreccio, Catterina4 aut |
700 | 1 | a Akena, Dickens4 aut |
700 | 1 | a Brayne, Carol4 aut |
700 | 1 | a Maestre, Gladys4 aut |
700 | 1 | a Blangero, Sarah Williams4 aut |
700 | 1 | a Brusco, Luis I4 aut |
700 | 1 | a Siddarth, Prabha4 aut |
700 | 1 | a Hughes, Timothy M4 aut |
700 | 1 | a Zuñiga, Alfredo Ramírez4 aut |
700 | 1 | a Kambeitz, Joseph4 aut |
700 | 1 | a Laza, Agustin Ruiz4 aut |
700 | 1 | a Allen, Norrina4 aut |
700 | 1 | a Panos, Stella4 aut |
700 | 1 | a Merrill, David4 aut |
700 | 1 | a Ibáñez, Agustín4 aut |
700 | 1 | a Tsuang, Debby4 aut |
700 | 1 | a Valishvili, Nino4 aut |
700 | 1 | a Shrestha, Srishti4 aut |
700 | 1 | a Wang, Sophia4 aut |
700 | 1 | a Padma, Vasantha4 aut |
700 | 1 | a Anstey, Kaarin J4 aut |
700 | 1 | a Ravindrdanath, Vijayalakshmi4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Mullins, Paul4 aut |
700 | 1 | a Łojek, Emilia4 aut |
700 | 1 | a Pria, Anand4 aut |
700 | 1 | a Mosley, Thomas H4 aut |
700 | 1 | a Gowland, Penny4 aut |
700 | 1 | a Girard, Timothy D4 aut |
700 | 1 | a Bowtell, Richard4 aut |
700 | 1 | a Vahidy, Farhaan S4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alzheimer's & dementia (New York, N. Y.)d : Wileyg 8:1q 8:1x 2352-8737 |
856 | 4 8 | u https://gup.ub.gu.se/publication/322192 |
856 | 4 8 | u https://doi.org/10.1002/trc2.12348 |
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