Sökning: (WFRF:(Vilarino Gueell Carles)) pers:(Lynch Timothy) > (2011) > Independent and Joi...
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000 | 05559naa a2200865 4500 | |
001 | oai:lup.lub.lu.se:8878d820-0fee-4bdf-808b-b2df4d597a7d | |
003 | SwePub | |
008 | 160401s2011 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:122501356 | |
024 | 7 | a https://lup.lub.lu.se/record/19881262 URI |
024 | 7 | a https://doi.org/10.1002/ana.223212 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1225013562 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Elbaz, Alexis4 aut |
245 | 1 0 | a Independent and Joint Effects of the MAPT and SNCA Genes in Parkinson Disease |
264 | c 2011-03-09 | |
264 | 1 | b Wiley,c 2011 |
520 | a Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. Methods: Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case-control and case-only approach. Results: Fifteen GEO-PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 SNCA SNPs and the MAPT H1-haplotype-defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 30 end of the gene. There was no evidence of statistical interaction between any of the 4 SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale. Interpretation: This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects. ANN NEUROL 2011; 69: 778-792 | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
700 | 1 | a Ross, Owen A.4 aut |
700 | 1 | a Ioannidis, John P. A.4 aut |
700 | 1 | a Soto-Ortolaza, Alexandra I.4 aut |
700 | 1 | a Moisan, Frederic4 aut |
700 | 1 | a Aasly, Jan4 aut |
700 | 1 | a Annesi, Grazia4 aut |
700 | 1 | a Bozi, Maria4 aut |
700 | 1 | a Brighina, Laura4 aut |
700 | 1 | a Chartier-Harlin, Marie-Christine4 aut |
700 | 1 | a Destee, Alain4 aut |
700 | 1 | a Ferrarese, Carlo4 aut |
700 | 1 | a Ferraris, Alessandro4 aut |
700 | 1 | a Gibson, J. Mark4 aut |
700 | 1 | a Gispert, Suzana4 aut |
700 | 1 | a Hadjigeorgiou, Georgios M.4 aut |
700 | 1 | a Jasinska-Myga, Barbara4 aut |
700 | 1 | a Klein, Christine4 aut |
700 | 1 | a Krueger, Rejko4 aut |
700 | 1 | a Lambert, Jean-Charles4 aut |
700 | 1 | a Lohmann, Katja4 aut |
700 | 1 | a van de Loo, Simone4 aut |
700 | 1 | a Loriot, Marie-Anne4 aut |
700 | 1 | a Lynch, Timothy4 aut |
700 | 1 | a Mellick, George D.4 aut |
700 | 1 | a Mutez, Eugenie4 aut |
700 | 1 | a Nilsson, Christeru Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-cni |
700 | 1 | a Opala, Grzegorz4 aut |
700 | 1 | a Puschmann, Andreasu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-aps |
700 | 1 | a Quattrone, Aldo4 aut |
700 | 1 | a Sharma, Manu4 aut |
700 | 1 | a Silburn, Peter A.4 aut |
700 | 1 | a Stefanis, Leonidas4 aut |
700 | 1 | a Uitti, Ryan J.4 aut |
700 | 1 | a Valente, Enza Maria4 aut |
700 | 1 | a Vilarino-Gueell, Carles4 aut |
700 | 1 | a Wirdefeldt, Karinu Karolinska Institutet4 aut |
700 | 1 | a Wszolek, Zbigniew K.4 aut |
700 | 1 | a Xiromerisiou, Georgia4 aut |
700 | 1 | a Maraganore, Demetrius M.4 aut |
700 | 1 | a Farrer, Matthew J.4 aut |
710 | 2 | a Psykiatri, Lundb Sektion IV4 org |
773 | 0 | t Annals of Neurologyd : Wileyg 69:5, s. 778-792q 69:5<778-792x 1531-8249x 0364-5134 |
856 | 4 | u http://dx.doi.org/10.1002/ana.22321y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc3082599?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/1988126 |
856 | 4 8 | u https://doi.org/10.1002/ana.22321 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:122501356 |
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