Evidence of a negative feedback system regulating the total beta-cell volume in nondiabetic rats that received pancreas transplants

Wahlberg, Jeanette, 1969- (author): Department of Medical Cell Biology, Uppsala University, Sweden

Korsgren, O. (author): Department of Clinical Immunology and Transfusion Medicine, Uppsala University Hospital, Uppsala, Sweden,Department of Medical Cell Biology, Uppsala University, Sweden.

Welsh, N. (author): Department of Medical Cell Biology, Uppsala University, Sweden.

Jansson, L. (author): Department of Medical Cell Biology, Uppsala University, Sweden.

(creator_code:org_t)

Lippincott Williams & Wilkins, 1998
1998
English.
In: Transplantation. - : Lippincott Williams & Wilkins. - 0041-1337 .- 1534-6080. ; 66:10, s. 1392-1394

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Abstract Subject headings

BACKGROUND: The aim of the present study was to investigate the long-term regulation of pancreatic beta-cell volume after pancreas transplantation into adult rats.METHODS: A syngeneic pancreaticoduodenal transplantation was made in normoglycemic Wistar-Furth rats. By this means, the recipients doubled their pancreatic islet volume. Nine months after transplantation, the total beta-cell volume was measured in serial pancreatic sections immunostained for insulin from both the native and transplanted pancreata, and in the native pancreas of age-matched Wistar-Furth rats that did not receive transplants.RESULTS: No changes in the volume of individual beta-cells were seen. A 50% decrease in total beta-cell volume was observed in both the native and transplanted pancreas when compared with that of age-matched controls. However, the combined beta-cell volumes of the native and transplanted pancreas in the rats that received transplants were similar to those of the native pancreas in control animals. No signs of increased apoptosis in any of the glands could be seen during the first postoperative week or after 9 months.CONCLUSIONS: These findings provide evidence of a negative feedback system, which regulates the total beta-cell volume to the levels seen in age-matched rats that did not receive transplants. The underlying mechanisms for the decreased beta-cell volume are unknown, but may involve a diminished replicatory rate of the beta-cells.

By the author/editor: Wahlberg, Jeanet ...; Korsgren, O.; Welsh, N.; Jansson, L.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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