Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG

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Fältnamn	Indikatorer	Metadata
000		05492naa a2201021 4500
001		oai:DiVA.org:umu-52366
003		SwePub
008		120220s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:123955487
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-523662 URI
024	7	a https://doi.org/10.1002/pros.214432 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1239554872 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Lu, Lingyi4 aut
245	1 0	a Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG
264		c 2011-07-11
264	1	b Wiley,c 2012
338		a print2 rdacarrier
520		a BACKGROUND In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite-based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD?=?1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members. METHODS. In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome-wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups. RESULTS. Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37cM interval on 4q13-25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD cores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC, an important gene in PC biology. CONCLUSIONS. These results will be useful in prioritizing future susceptibility gene discovery efforts in thiscommon cancer. Prostate 72: 410-426, 2012. (C) 2011 Wiley Periodicals, Inc.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Cancel-Tassin, Geraldine4 aut
700	1	a Valeri, Antoine4 aut
700	1	a Cussenot, Olivier4 aut
700	1	a Lange, Ethan M.4 aut
700	1	a Cooney, Kathleen A.4 aut
700	1	a Farnham, James M.4 aut
700	1	a Camp, Nicola J.4 aut
700	1	a Cannon-Albright, Lisa A.4 aut
700	1	a Tammela, Teuvo L. J.4 aut
700	1	a Schleutker, Johanna4 aut
700	1	a Hoegel, Josef4 aut
700	1	a Herkommer, Kathleen4 aut
700	1	a Maier, Christiane4 aut
700	1	a Vogel, Walther4 aut
700	1	a Wiklund, Fredriku Karolinska Institutet4 aut
700	1	a Emanuelsson, Monicau Umeå universitet,Onkologi4 aut0 (Swepub:umu)moem0001
700	1	a Groenberg, Henriku Karolinska Institutet4 aut
700	1	a Wiley, Kathleen E.4 aut
700	1	a Isaacs, Sarah D.4 aut
700	1	a Walsh, Patrick C.4 aut
700	1	a Helfand, Brian T.4 aut
700	1	a Kan, Donghui4 aut
700	1	a Catalona, William J.4 aut
700	1	a Stanford, Janet L.4 aut
700	1	a FitzGerald, Liesel M.4 aut
700	1	a Johanneson, Bo4 aut
700	1	a Deutsch, Kerry4 aut
700	1	a McIntosh, Laura4 aut
700	1	a Ostrander, Elaine A.4 aut
700	1	a Thibodeau, Stephen N.4 aut
700	1	a McDonnell, Shannon K.4 aut
700	1	a Hebbring, Scott4 aut
700	1	a Schaid, Daniel J.4 aut
700	1	a Whittemore, Alice S.4 aut
700	1	a Oakley-Girvan, Ingrid4 aut
700	1	a Hsieh, Chih-Lin4 aut
700	1	a Powell, Isaac4 aut
700	1	a Bailey-Wilson, Joan E.4 aut
700	1	a Cropp, Cheryl D.4 aut
700	1	a Simpson, Claire4 aut
700	1	a Carpten, John D.4 aut
700	1	a Seminara, Daniela4 aut
700	1	a Zheng, S. Lilly4 aut
700	1	a Xu, Jianfen4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Hopper, John L.4 aut
700	1	a English, Dallas R.4 aut
700	1	a Foulkes, William D.4 aut
700	1	a Maehle, Lovise4 aut
700	1	a Moller, Pal4 aut
700	1	a Badzioch, Michael D.4 aut
700	1	a Edwards, Steve4 aut
700	1	a Guy, Michelle4 aut
700	1	a Eeles, Ros4 aut
700	1	a Easton, Douglas4 aut
700	1	a Isaacs, William B.4 aut
710	2	a Karolinska Institutetb Onkologi4 org
773	0	t The Prostated : Wileyg 72:4, s. 410-426q 72:4<410-426x 0270-4137x 1097-0045
856	4	u https://europepmc.org/articles/pmc3568777?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52366
856	4 8	u https://doi.org/10.1002/pros.21443
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:123955487

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By the author/editor: Lu, Lingyi; Cancel-Tassin, G ...; Valeri, Antoine; Cussenot, Olivie ...; Lange, Ethan M.; Cooney, Kathleen ...; show more...; Farnham, James M ...; Camp, Nicola J.; Cannon-Albright, ...; Tammela, Teuvo L ...; Schleutker, Joha ...; Hoegel, Josef; Herkommer, Kathl ...; Maier, Christian ...; Vogel, Walther; Wiklund, Fredrik; Emanuelsson, Mon ...; Groenberg, Henri ...; Wiley, Kathleen ...; Isaacs, Sarah D.; Walsh, Patrick C ...; Helfand, Brian T ...; Kan, Donghui; Catalona, Willia ...; Stanford, Janet ...; FitzGerald, Lies ...; Johanneson, Bo; Deutsch, Kerry; McIntosh, Laura; Ostrander, Elain ...; Thibodeau, Steph ...; McDonnell, Shann ...; Hebbring, Scott; Schaid, Daniel J ...; Whittemore, Alic ...; Oakley-Girvan, I ...; Hsieh, Chih-Lin; Powell, Isaac; Bailey-Wilson, J ...; Cropp, Cheryl D.; Simpson, Claire; Carpten, John D.; Seminara, Daniel ...; Zheng, S. Lilly; Xu, Jianfen; Giles, Graham G.; Severi, Gianluca; Hopper, John L.; English, Dallas ...; Foulkes, William ...; Maehle, Lovise; Moller, Pal; Badzioch, Michae ...; Edwards, Steve; Guy, Michelle; Eeles, Ros; Easton, Douglas; Isaacs, William ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: The Prostate

By the university: Umeå University; Karolinska Institutet

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