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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07621naa a2201909 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:139028587 | |
| 003 | SwePub | |
| 008 | 240701s2018 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-368158 | |
| 009 | oai:lup.lub.lu.se:9b22f688-0605-4a6c-a1c4-ea27adeb923f | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1390285872 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-018-05427-72 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3681582 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/9b22f688-0605-4a6c-a1c4-ea27adeb923f2 URI |
| 040 | a (SwePub)kid (SwePub)uud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a O'Mara, TAu QIMR Berghofer Medical Research Institute4 aut |
| 245 | 1 0 | a Identification of nine new susceptibility loci for endometrial cancer |
| 264 | c 2018-08-09 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2018 |
| 520 | a Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Glubb, DM4 aut |
| 700 | 1 | a Amant, F4 aut |
| 700 | 1 | a Annibali, D4 aut |
| 700 | 1 | a Ashton, K4 aut |
| 700 | 1 | a Attia, J4 aut |
| 700 | 1 | a Auer, PL4 aut |
| 700 | 1 | a Beckmann, MW4 aut |
| 700 | 1 | a Black, A4 aut |
| 700 | 1 | a Bolla, MK4 aut |
| 700 | 1 | a Brauch, H4 aut |
| 700 | 1 | a Brenner, H4 aut |
| 700 | 1 | a Brinton, L4 aut |
| 700 | 1 | a Buchanan, DD4 aut |
| 700 | 1 | a Burwinkel, B4 aut |
| 700 | 1 | a Chang-Claude, J4 aut |
| 700 | 1 | a Chanock, SJ4 aut |
| 700 | 1 | a Chen, C4 aut |
| 700 | 1 | a Chen, MM4 aut |
| 700 | 1 | a Cheng, THT4 aut |
| 700 | 1 | a Clarke, CL4 aut |
| 700 | 1 | a Clendenning, M4 aut |
| 700 | 1 | a Cook, LS4 aut |
| 700 | 1 | a Couch, FJ4 aut |
| 700 | 1 | a Cox, A4 aut |
| 700 | 1 | a Crous-Bous, M4 aut |
| 700 | 1 | a Czene, Ku Karolinska Institutet4 aut |
| 700 | 1 | a Day, F4 aut |
| 700 | 1 | a Dennis, J4 aut |
| 700 | 1 | a Depreeuw, J4 aut |
| 700 | 1 | a Doherty, JA4 aut |
| 700 | 1 | a Dork, T4 aut |
| 700 | 1 | a Dowdy, SC4 aut |
| 700 | 1 | a Durst, M4 aut |
| 700 | 1 | a Ekici, AB4 aut |
| 700 | 1 | a Fasching, PA4 aut |
| 700 | 1 | a Fridley, BL4 aut |
| 700 | 1 | a Friedenreich, CM4 aut |
| 700 | 1 | a Fritschi, L4 aut |
| 700 | 1 | a Fung, J4 aut |
| 700 | 1 | a Garcia-Closas, M4 aut |
| 700 | 1 | a Gaudet, MM4 aut |
| 700 | 1 | a Giles, GG4 aut |
| 700 | 1 | a Goode, EL4 aut |
| 700 | 1 | a Gorman, M4 aut |
| 700 | 1 | a Haiman, CA4 aut |
| 700 | 1 | a Hall, Pu Karolinska Institutet4 aut |
| 700 | 1 | a Hankison, SE4 aut |
| 700 | 1 | a Healey, CS4 aut |
| 700 | 1 | a Hein, A4 aut |
| 700 | 1 | a Hillemanns, P4 aut |
| 700 | 1 | a Hodgson, S4 aut |
| 700 | 1 | a Hoivik, EA4 aut |
| 700 | 1 | a Holliday, EG4 aut |
| 700 | 1 | a Hopper, JL4 aut |
| 700 | 1 | a Hunter, DJ4 aut |
| 700 | 1 | a Jones, A4 aut |
| 700 | 1 | a Krakstad, C4 aut |
| 700 | 1 | a Kristensen, VN4 aut |
| 700 | 1 | a Lambrechts, D4 aut |
| 700 | 1 | a Le Marchand, L4 aut |
| 700 | 1 | a Liang, XL4 aut |
| 700 | 1 | a Lindblom, Au Karolinska Institutet4 aut |
| 700 | 1 | a Lissowska, J4 aut |
| 700 | 1 | a Long, JR4 aut |
| 700 | 1 | a Lu, LG4 aut |
| 700 | 1 | a Magliocco, AM4 aut |
| 700 | 1 | a Martin, L4 aut |
| 700 | 1 | a McEvoy, M4 aut |
| 700 | 1 | a Meindl, A4 aut |
| 700 | 1 | a Michailidou, K4 aut |
| 700 | 1 | a Milne, RL4 aut |
| 700 | 1 | a Mints, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Montgomery, GW4 aut |
| 700 | 1 | a Nassir, R4 aut |
| 700 | 1 | a Olsson, Håkanu Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups4 aut0 (Swepub:lu)onk-hol |
| 700 | 1 | a Orlow, I4 aut |
| 700 | 1 | a Otton, G4 aut |
| 700 | 1 | a Palles, C4 aut |
| 700 | 1 | a Perry, JRB4 aut |
| 700 | 1 | a Peto, J4 aut |
| 700 | 1 | a Pooler, L4 aut |
| 700 | 1 | a Prescott, J4 aut |
| 700 | 1 | a Proietto, T4 aut |
| 700 | 1 | a Rebbeck, TR4 aut |
| 700 | 1 | a Risch, HA4 aut |
| 700 | 1 | a Wolk, Alicjau Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)alwol516 |
| 700 | 1 | a Rubner, M4 aut |
| 700 | 1 | a Runnebaum, I4 aut |
| 700 | 1 | a Sacerdote, C4 aut |
| 700 | 1 | a Sarto, GE4 aut |
| 700 | 1 | a Schumacher, F4 aut |
| 700 | 1 | a Scott, RJ4 aut |
| 700 | 1 | a Setiawan, VW4 aut |
| 700 | 1 | a Shah, M4 aut |
| 700 | 1 | a Sheng, X4 aut |
| 700 | 1 | a Shu, XO4 aut |
| 700 | 1 | a Southey, MC4 aut |
| 700 | 1 | a Swerdlow, AJ4 aut |
| 700 | 1 | a Tham, Eu Karolinska Institutet4 aut |
| 700 | 1 | a Trovik, J4 aut |
| 700 | 1 | a Turman, C4 aut |
| 700 | 1 | a Tyrer, JP4 aut |
| 700 | 1 | a Vachon, C4 aut |
| 700 | 1 | a Vanden Berg, D4 aut |
| 700 | 1 | a Vanderstichele, A4 aut |
| 700 | 1 | a Wang, ZM4 aut |
| 700 | 1 | a Webb, PM4 aut |
| 700 | 1 | a Wentzensen, N4 aut |
| 700 | 1 | a Werner, HMJ4 aut |
| 700 | 1 | a Winham, SJ4 aut |
| 700 | 1 | a Wolk, Au Karolinska Institutet4 aut |
| 700 | 1 | a Xia, L4 aut |
| 700 | 1 | a Xiang, YB4 aut |
| 700 | 1 | a Yang, HP4 aut |
| 700 | 1 | a Yu, H4 aut |
| 700 | 1 | a Zheng, W4 aut |
| 700 | 1 | a Pharoah, PDP4 aut |
| 700 | 1 | a Dunning, AM4 aut |
| 700 | 1 | a Kraft, P4 aut |
| 700 | 1 | a De Vivo, I4 aut |
| 700 | 1 | a Tomlinson, I4 aut |
| 700 | 1 | a Easton, DF4 aut |
| 700 | 1 | a Spurdle, AB4 aut |
| 700 | 1 | a Thompson, DJu University of Cambridge4 aut |
| 710 | 2 | a Karolinska Institutetb QIMR Berghofer Medical Research Institute4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 9:1, s. 3166-q 9:1<3166-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-018-05427-7.pdf |
| 856 | 4 | u https://doi.org/10.1038/s41467-018-05427-7y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1267935/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://dx.doi.org/10.1038/s41467-018-05427-7x freey FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139028587 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-018-05427-7 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368158 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/9b22f688-0605-4a6c-a1c4-ea27adeb923f |
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