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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04207naa a2200445 4500 | |
| 001 | oai:DiVA.org:sh-45214 | |
| 003 | SwePub | |
| 008 | 210421s2003 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:hj-27956 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-452142 URI |
| 024 | 7 | a https://doi.org/10.2190/PFFD-D920-V041-N5KD2 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-279562 URI |
| 040 | a (SwePub)shd (SwePub)hj | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Shor-Posner, G.u Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 aut |
| 245 | 1 0 | a Psychological burden in the era of Haart :b Impact of selenium therapy |
| 264 | 1 | b Sage Publications,c 2003 |
| 338 | a print2 rdacarrier | |
| 520 | a Objective: To determine the impact of nutritional (selenium) chemoprevention on levels of psychological burden (anxiety, depression, and mood state) in HIV/AIDS. Method: A randomized, double-blind, placebo-controlled selenium therapy (200 mug/day) trial was conducted in HIV+ drug users from 1998-2000. Psychosocial measures (STAI-State and Trait anxiety, BDI-depression, and POMS- mood state), clinical status (CD4 cell count, viral load), and plasma selenium levels were determined at baseline and compared with measurements obtained at the 12-month evaluation in 63 participants (32 men, 31 women). Results: The majority of the study participants reported elevated levels of both State (68%) and Trait (70%) anxiety. Approximately 25% reported overall mood distress (POMS > 60) and moderate depression (BDI > 20). Psychological burden was not influenced by current drug use, antiretroviral treatment, or viral load. At the 12-month evaluation, participants who received selenium reported increased vigor (p = 0.004) and had less anxiety (State, p = 0.05 and Trait, p = 0.02), compared to the placebo-treated individuals. No apparent selenium-related affect on depression or distress was observed. The risk for state anxiety was almost four times higher, and nearly nine times greater for trait anxiety in the placebo-treated group, controlling for antiretroviral therapy, CD4 cell decline (> 50 cells) and years of education. Conclusions: Selenium therapy may be a beneficial treatment to decrease anxiety in HIV+ drug users who exhibit a high prevalence of psychological burden. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 653 | a anxiety | |
| 653 | a HIV infection | |
| 653 | a selenium | |
| 700 | 1 | a Lecusay, Robert,d 1974-u Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 aut0 (Swepub:hj)lecrob |
| 700 | 1 | a Miguez, M. J.u Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 aut |
| 700 | 1 | a Moreno-Black, G.u Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 aut |
| 700 | 1 | a Zhang, G. Y.u Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 aut |
| 700 | 1 | a Rodriguez, N.u Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 aut |
| 700 | 1 | a Burbano, X.u Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 aut |
| 700 | 1 | a Baum, M.u Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 aut |
| 700 | 1 | a Wilkie, F.u Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 aut |
| 710 | 2 | a Dept. of Psychiat./Behav. Sci. (D21), Division of Disease Prevention, Miami, United States4 org |
| 773 | 0 | t International Journal of Psychiatry in Medicined : Sage Publicationsg 33:1, s. 55-69q 33:1<55-69x 0091-2174x 1541-3527 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-45214 |
| 856 | 4 8 | u https://doi.org/10.2190/PFFD-D920-V041-N5KD |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-27956 |
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