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Genome-wide associa...
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Cai, LinaUniversity of Cambridge
(author)
Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-11-13
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Nature Publishing Group,2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-178114
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178114URI
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https://doi.org/10.1038/s41597-020-00716-7DOI
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https://lup.lub.lu.se/record/fef5ff0c-bfc5-43f0-974f-6ec15c6340f2URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wheeler, EleanorUniversity of Cambridge
(author)
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Kerrison, Nicola D.University of Cambridge
(author)
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Luan, Jian'anUniversity of Cambridge
(author)
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Deloukas, PanosQueen Mary University
(author)
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Franks, Paul W.Umeå University,Lund University,Lunds universitet,Umeå universitet,Näringsforskning,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, 20502, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf
(author)
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Amiano, PilarBiodonostia Health Research Institute
(author)
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Ardanaz, EvaHealth Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05
(author)
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Bonet, CatalinaBellvitge Biomedical Research Institute
(author)
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Fagherazzi, GuyLuxembourg Institute of Health,Institut Gustave Roussy
(author)
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Groop, Leif C.Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-lgr
(author)
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Kaaks, RudolfGerman Cancer Research Centre
(author)
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Huerta, Jose MariaMurcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Masala, GiovannaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO)
(author)
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Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-pni
(author)
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Overvad, KimAarhus University,Aalborg University Hospital
(author)
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Pala, ValeriaIstituto Nazionale dei Tumori
(author)
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Panico, SalvatoreUniversity of Naples Federico II
(author)
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Rodriguez-Barranco, MiguelAndalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Rolandsson, OlovUmeå University,Umeå universitet,Allmänmedicin(Swepub:umu)olro0005
(author)
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Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin
(author)
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Schulze, Matthias B.University of Potsdam,German Center for Diabetes Research
(author)
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Spijkerman, Annemieke M. W.National Institute for Public Health and the Environment (RIVM)
(author)
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Tjonneland, AnneDanish Cancer Society
(author)
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Tumino, Rosario
(author)
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van der Schouw, Yvonne T.University Medical Center Utrecht
(author)
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Sharp, Stephen J.University of Cambridge
(author)
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Forouhi, Nita G.University of Cambridge
(author)
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Riboli, ElioImperial College London
(author)
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McCarthy, Mark I.University of Oxford,Wellcome Trust Centre for Human Genetics,Oxford University Hospital
(author)
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Barroso, InesUniversity of Exeter
(author)
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Langenberg, ClaudiaUniversity of Cambridge
(author)
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Wareham, Nicholas J.University of Cambridge
(author)
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University of CambridgeQueen Mary University
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In:Scientific Data: Nature Publishing Group7:12052-4463
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Cai, Lina
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Wheeler, Eleanor
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Kerrison, Nicola ...
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Luan, Jian'an
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Deloukas, Panos
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Franks, Paul W.
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Amiano, Pilar
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Ardanaz, Eva
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Bonet, Catalina
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Fagherazzi, Guy
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Groop, Leif C.
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Kaaks, Rudolf
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Huerta, Jose Mar ...
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Masala, Giovanna
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Nilsson, Peter M ...
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Overvad, Kim
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Pala, Valeria
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Panico, Salvator ...
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Rodriguez-Barran ...
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Rolandsson, Olov
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Sacerdote, Carlo ...
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Schulze, Matthia ...
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Spijkerman, Anne ...
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Tjonneland, Anne
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Tumino, Rosario
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van der Schouw, ...
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Sharp, Stephen J ...
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Forouhi, Nita G.
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Riboli, Elio
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McCarthy, Mark I ...
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Barroso, Ines
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Langenberg, Clau ...
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