Sökning: (hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Neurologi)) pers:(Englund Elisabet) > Evaluation of clini...
Fältnamn | Indikatorer | Metadata |
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000 | 05406naa a2200625 4500 | |
001 | oai:DiVA.org:umu-79157 | |
003 | SwePub | |
008 | 130810s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:c6361743-fc8b-4695-bc77-a5a6aad6d270 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-791572 URI |
024 | 7 | a https://doi.org/10.1016/j.pcd.2013.04.0042 DOI |
024 | 7 | a https://lup.lub.lu.se/record/44397522 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Pourhamidi, Kavehu Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)kahpoi04 |
245 | 1 0 | a Evaluation of clinical tools and their diagnostic use in distal symmetric polyneuropathy |
264 | 1 | b Elsevier,c 2014 |
338 | a print2 rdacarrier | |
520 | a AIMS: To compare the diagnostic usefulness of tuning fork, monofilament, biothesiometer and skin biopsies in peripheral neuropathy in individuals with varying glucose metabolism.METHODS: Normoglycaemic, impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) individuals were recruited. Nerve conduction studies (NCS) and thermal threshold tests were performed. Vibrotactile sense was tested with a biothesiometer and a 128-Hz tuning fork. Touch/pressure perception was examined with a 10-g monofilament. Skin biopsies were performed and intraepidermal nerve fibres were quantified. Distal symmetric polyneuropathy (DSPN) was defined as neuropathy disability score ≥2 and abnormal NCS. Thermal threshold tests were used to define small nerve fibre neuropathy (sDSPN) in cases where NCS (large nerve fibres) were normal.RESULTS: The prevalence of DSPN and sDSPN in the whole group (n=119) was 18% and 23%, respectively. For the biothesiometer, a cut-off of ≥24.5V had a sensitivity of 82% and specificity of 70% (AUC=0.81, 95% CI 0.71-0.91) when evaluating DSPN. An intraepidermal nerve fibre density cut-off of ≤3.39fibres/mm showed a sensitivity of 74% and specificity of 70% in the detection of sDSPN, whereas the sensitivity of the tuning fork and the biothesiometer were relatively low, 46% and 67%, respectively. When combining skin biopsies with the tuning fork, 10 more sDSPN cases were identified. Adding skin biopsy to the combination of the tuning fork and biothesiometer increased the sensitivity of finding sDSPN cases, but not DSPN, from 81% to 93%.CONCLUSION: Using a biothesiometer in clinical routine might be a sensitive method to detect large nerve fibre dysfunction in the lower extremity, whereas skin biopsies in combination with methods measuring vibrotactile sense could increase the diagnostic sensitivity of detecting peripheral neuropathy at an early stage. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Biothesiometer | |
653 | a Diabetes mellitus | |
653 | a Nerve fibres | |
653 | a Neuropathy | |
653 | a Skin biopsy | |
653 | a Biothesiometer | |
653 | a Diabetes mellitus | |
653 | a Nerve fibres | |
653 | a Neuropathy | |
653 | a Skin biopsy | |
700 | 1 | a Dahlin, Larsu Lund University,Lunds universitet,Handkirurgi, Malmö,Forskargrupper vid Lunds universitet,Hand Surgery, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)hand-lda |
700 | 1 | a Englund, Elisabetu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-een |
700 | 1 | a Rolandsson, Olovu Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)olro0005 |
710 | 2 | a Umeå universitetb Allmänmedicin4 org |
773 | 0 | t Primary care diabetesd : Elsevierg 8:1, s. 77-84q 8:1<77-84x 1878-0210x 1751-9918 |
856 | 4 | u https://lup.lub.lu.se/search/files/1940318/5152955.pdf |
856 | 4 | u https://portal.research.lu.se/files/1940318/5152955.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1016/j.pcd.2013.04.004y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79157 |
856 | 4 8 | u https://doi.org/10.1016/j.pcd.2013.04.004 |
856 | 4 8 | u https://lup.lub.lu.se/record/4439752 |
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