Sökning: (id:"swepub:oai:DiVA.org:uu-421531") >
Diagnostic performa...
Diagnostic performance of initial blood urea nitrogen combined with D-dimer levels for predicting in-hospital mortality in COVID-19 patients
-
- Cheng, Anying (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nephrol, Wuhan, Peoples R China.
-
- Hu, Liu (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hlth Management Ctr, Wuhan, Peoples R China.
-
- Wang, Yiru (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nephrol, Wuhan, Peoples R China.
-
visa fler...
-
- Huang, Luyan (författare)
- Wuhan Hosp Tradit Chinese Med, Dept Anesthesiol, Hanyang Branch, Wuhan, Peoples R China.
-
- Zhao, Lingxi (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hlth Management Ctr, Wuhan, Peoples R China.
-
- Zhang, Congcong (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hlth Management Ctr, Wuhan, Peoples R China.
-
- Liu, Xiyue (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hlth Management Ctr, Wuhan, Peoples R China.
-
- Xu, Ranran (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nephrol, Wuhan, Peoples R China.
-
- Liu, Feng (författare)
- Univ South China, Cent Hosp Shaoyang, Dept Urol, Hengyang, Peoples R China.
-
- Li, Jin-Ping (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
- Ye, Dawei (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Canc Ctr, Wuhan, Peoples R China.
-
- Wang, Tao (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Ctr Biomed Res,NHC Key Lab Resp Dis, Wuhan, Peoples R China.
-
- Lv, Yongman (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nephrol, Wuhan, Peoples R China.;Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hlth Management Ctr, Wuhan, Peoples R China.
-
- Liu, Qingquan (författare)
- Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nephrol, Wuhan, Peoples R China.
-
visa färre...
-
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nephrol, Wuhan, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hlth Management Ctr, Wuhan, Peoples R China. (creator_code:org_t)
- ELSEVIER, 2020
- 2020
- Engelska.
-
Ingår i: International Journal of Antimicrobial Agents. - : ELSEVIER. - 0924-8579 .- 1872-7913. ; 56:3
- Relaterad länk:
-
https://europepmc.or...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The crude mortality rate in critical pneumonia cases with coronavirus disease 2019 (COVID-19) reaches 49%. This study aimed to test whether levels of blood urea nitrogen (BUN) in combination with D-dimer were predictors of in-hospital mortality in COVID-19 patients. The clinical characteristics of 305 COVID19 patients were analysed and were compared between the survivor and non-survivor groups. Of the 305 patients, 85 (27.9%) died and 220 (72.1%) were discharged from hospital. Compared with discharged cases, non-survivor cases were older and their BUN and D-dimer levels were significantly higher ( P < 0.0 0 01). Least absolute shrinkage and selection operator (LASSO) and multivariable Cox regression analyses identified BUN and D-dimer levels as independent risk factors for poor prognosis. Kaplan-Meier analysis showed that elevated levels of BUN and D-dimer were associated with increased mortality (logrank, P 0.0 0 01). The area under the curve for BUN combined with D-dimer was 0.94 (95% CI 0.90-0.97), with a sensitivity of 85% and specificity of 91%. Based on BUN and D-dimer levels on admission, a nomogram model was developed that showed good discrimination, with a concordance index of 0.94. Together, initial BUN and D-dimer levels were associated with mortality in COVID-19 patients. The combination of BUN 4.6 mmol/L and D-dimer > 0.845 mu g/mL appears to identify patients at high risk of in-hospital mortality, therefore it may prove to be a powerful risk assessment tool for severe COVID-19 patients. (c) 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- COVID-19
- Blood urea nitrogen
- D-dimer
- Viral pneumonia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Cheng, Anying
-
Hu, Liu
-
Wang, Yiru
-
Huang, Luyan
-
Zhao, Lingxi
-
Zhang, Congcong
-
visa fler...
-
Liu, Xiyue
-
Xu, Ranran
-
Liu, Feng
-
Li, Jin-Ping
-
Ye, Dawei
-
Wang, Tao
-
Lv, Yongman
-
Liu, Qingquan
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Uppsala universitet