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Earlier Alzheimer’s...
Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
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- Frontzkowski, Lukas (author)
- University Hospital Munich
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- Ewers, Michael (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Munich
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- Brendel, Matthias (author)
- Munich Cluster for Systems Neurology,University Hospital Munich
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- Biel, Davina (author)
- University Hospital Munich
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam
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- Hager, Paul (author)
- University Hospital Munich
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- Steward, Anna (author)
- University Hospital Munich
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- Dewenter, Anna (author)
- University Hospital Munich
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- Römer, Sebastian (author)
- University Hospital Munich
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- Rubinski, Anna (author)
- University Hospital Munich
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- Buerger, Katharina (author)
- University Hospital Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Janowitz, Daniel (author)
- University Hospital Munich
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- Binette, Alexa Pichet (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Smith, Ruben (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Strandberg, Olof (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,MR Physics,Clinical Memory Research,Lund University Research Groups
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- Carlgren, Niklas Mattsson (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Dichgans, Martin (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Munich Cluster for Systems Neurology,University Hospital Munich
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Franzmeier, Nicolai (author)
- University Hospital Munich,Munich Cluster for Systems Neurology
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(creator_code:org_t)
- 2022-08-20
- 2022
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
- Related links:
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- In Alzheimer’s disease (AD), younger symptom onset is associated with accelerated disease progression and tau spreading, yet the mechanisms underlying faster disease manifestation are unknown. To address this, we combined resting-state fMRI and longitudinal tau-PET in two independent samples of controls and biomarker-confirmed AD patients (ADNI/BioFINDER, n = 240/57). Consistent across both samples, we found that younger symptomatic AD patients showed stronger tau-PET in globally connected fronto-parietal hubs, i.e., regions that are critical for maintaining cognition in AD. Stronger tau-PET in hubs predicted faster subsequent tau accumulation, suggesting that tau in globally connected regions facilitates connectivity-mediated tau spreading. Further, stronger tau-PET in hubs mediated the association between younger age and faster tau accumulation in symptomatic AD patients, which predicted faster cognitive decline. These independently validated findings suggest that younger AD symptom onset is associated with stronger tau pathology in brain hubs, and accelerated tau spreading throughout connected brain regions and cognitive decline.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Frontzkowski, Lu ...
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Ewers, Michael
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Brendel, Matthia ...
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Biel, Davina
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Ossenkoppele, Ri ...
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Hager, Paul
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show more...
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Steward, Anna
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Dewenter, Anna
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Römer, Sebastian
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Rubinski, Anna
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Buerger, Kathari ...
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Janowitz, Daniel
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Binette, Alexa P ...
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Smith, Ruben
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Strandberg, Olof
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Carlgren, Niklas ...
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Dichgans, Martin
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Hansson, Oskar
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Franzmeier, Nico ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University