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> Liedberg Bo Professor
> Svensson Stefan Associate Professor >
Synthesis of Orthog...
Synthesis of Orthogonally Functionalized Oligosaccharides for Self-assembled Monolayers and as Multimodal Tools in Chemical Biology
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- Fyrner, Timmy (författare)
- Linköpings universitet,Institutionen för fysik, kemi och biologi,Tekniska högskolan
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- Konradsson, Peter, Professor (preses)
- Linköpings universitet,Organisk Kemi,Tekniska högskolan
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- Svensson, Stefan, Associate Professor (preses)
- Linköpings universitet,Organisk Kemi
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- Liedberg, Bo, Professor (preses)
- Linköpings universitet,Sensorvetenskap och Molekylfysik,Tekniska högskolan
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- Ellervik, Ulf, Professor (opponent)
- Institutionen för Organisk kemi, Lunds Universitet, Lund
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(creator_code:org_t)
- ISBN 9789175199061
- Linköping : Linköping University Electronic Press, 2012
- Engelska 65 s.
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Serie: Linköping Studies in Science and Technology. Dissertations, 0345-7524 ; 1442
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- This thesis covers different topics in the field of synthetic organic chemistry combined with the field of surface science and glycobiology.First, the text presents a series of orthogonally protected oligosaccharides (tri-, penta-, and heptasaccharides) of varying length and structures, which are synthesized with the aim of developing novel heterobifunctional biocompatible cross-linkers. Successful conjugation with different chemical handles is also described and used to illustrate the potential implementation of defined carbohydrate based compounds have potential use in biosensing applications. The results of incubation experiments using living cells indicate that the linker is incorporated into cell surfaces and enriched in microdomains.Second, synthesis of various saccharide-terminated alkane thiols immobilized on gold surfaces is reported. The protein adsorption and antifouling characteristics of these surfaces were investigated using model proteins and the common fouling organisms, Ulva linza and Balanus amphitrite.Further, oligo(lactose)-based thiols (di-, tetra-, and hexasaccharides) were synthesized and immobilized on gold nanoparticles to investigate how well these rigid, rod-like oligosaccharides can stabilize such nanoparticles for future use in constructing hybrid nanoparticles.Finally, the thesis describes synthesis of a systematic series of oligo(ethylene) glycols possessing either hydrogen- or methyl-terminated groups. Investigation of the fundamental characteristics of self-assembled monolayers, will give important insights into the design of protein repellant surfaces.
Nyckelord
- Oligosaccharide synthesis
- glycosylation
- thioglycosides
- orthogonally protected
- oligo(lactosides)
- spacer molecule
- heterobifunctional
- surface plasmon resonance
- lipid anchor
- self-assembled monolayers
- glyconanoparticles
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