Crystallization-induced secondary selection from a tandem driven dynamic combinatorial resolution process

• Crystallization-induced secondary selection from a tandem driven dynamic combinatorial library is presented. In a one-pot experiment, an initial nitroaldol equilibrium was kinetically driven by a tandem reaction resulting in a subsequent dynamic library of diastereoisomers. This library was then further driven by a phase change, resulting in amplification and isolation of a highly diastereomerically enriched and synthetically interesting isoindolinone.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

ASYMMETRIC-SYNTHESIS

DRUG DISCOVERY

SOLID-STATE

CHEMISTRY

LIBRARIES

REARRANGEMENT

LIGANDS

Organic chemistry

Organisk kemi

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)