L773:0028 2766
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Subcutaneous and intranasal administration of 1-deamino-8-d-arginine vasopressin in the assessment of renal concentration capacity
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- Tryding, Nils (author)
- Central Hospital Kristianstad
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- Sterner, Gunnar (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
- Berg, Bertel (author)
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- Harris, Alan (author)
- Lundin, S (author)
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- (creator_code:org_t)
- 2008-12-05
- 1987
- English.
- In: Nephron. - : S. Karger AG. - 0028-2766 .- 1660-8151 .- 2235-3186. ; 45:1, s. 27-30
- Journal article (peer-reviewed)
Abstract
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- Maximum urine concentration capacity was studied in healthy adults using different routes and doses of administration of 1-deamino-8-d-arginine vasopressin (DDAVP) - desmopressin. Plasma levels of DDAVP showed a dose-dependent increase after the subcutaneous but not after the intranasal administration. The effect on urine osmolality was similar but more prolonged after the subcutaneous as compared to the intranasal route. We conclude that subcutaneous injection is a simple and reliable way of administering DDAVP. A dose of 4 μg in adults is optimum diagnostically and it corresponds to 20-40 μg administered intranasally.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
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- Sterner, Gunnar
- Berg, Bertel
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