L773:0264 6021
Sökning: L773:0264 6021 > (1980-1989) > Barrett Alan J > Human low-Mr kinino...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03067naa a2200313 4500 | |
| 001 | oai:lup.lub.lu.se:65380b50-3920-493f-b0e7-36d9ce23c87c | |
| 003 | SwePub | |
| 008 | 160401s1986 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11036912 URI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Salvesen, Guy4 aut |
| 245 | 1 0 | a Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases. |
| 264 | 1 | c 1986 |
| 520 | a We point out that human low-Mr kininogen contains three cystatin-like sequences, rather than two, as had previously been thought. The protein was purified by affinity chromatography on carboxymethyl-papain-Sepharose, and subjected to limited proteolysis by trypsin and chymotrypsin. Fragments were isolated, and three corresponding to the individual cystatin-like domains were identified. By comparison with the known amino acid sequence of the protein they were numbered 1 to 3 from the N-terminus. Domain 1 was not found to have any inhibitory activity for cysteine proteinases, which is consistent with the absence of residues that are highly conserved in inhibitors of the cystatin superfamily, and have previously been suggested to be essential for activity. Domain 2 was a good inhibitor of chicken calpain, and also papain and cathepsin L. Domain 3 showed negligible inhibition of calpain, but inhibited papain and cathepsin L strongly. The probable arrangement of disulphide bonds in the heavy chain of low-Mr kininogen is deduced from the homology with the cystatins and other evidence contained in the present paper. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 700 | 1 | a Parkes, Catherine4 aut |
| 700 | 1 | a Abrahamson, Magnusu Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kkem-mab |
| 700 | 1 | a Grubb, Andersu Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kkem-agr |
| 700 | 1 | a Barrett, Alan J4 aut |
| 710 | 2 | a Avdelningen för klinisk kemi och farmakologib Institutionen för laboratoriemedicin4 org |
| 773 | 0 | t Biochemical Journalg 234:2, s. 429-434q 234:2<429-434x 0264-6021 |
| 856 | 4 | u http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1146582&blobtype=pdfx freey FULLTEXT |
| 856 | 4 | u http://www.biochemj.org/bj/234/0429/2340429.pdfx freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1103691 |
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