SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:0902 0063 OR L773:1399 0012
 

Sökning: L773:0902 0063 OR L773:1399 0012 > Acute rejection in ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003387naa a2200445 4500
001oai:lup.lub.lu.se:e4cff19f-84ea-436a-b0a1-28bd1df021df
003SwePub
008160401s2010 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/16739352 URI
0247 a https://doi.org/10.1111/j.1399-0012.2009.01093.x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Frei, Ulrich4 aut
2451 0a Acute rejection in low-toxicity regimens: clinical impact and risk factors in the Symphony study
264 c 2010-08-12
264 1b Wiley,c 2010
520 a The Symphony study assessed whether mycophenolate mofetil (MMF)-based regimens containing reduced doses of adjunct immunosuppressants could reduce toxicity while maintaining efficacy. Here, we examined the impact of acute rejection and associated risk factors. The incidence of biopsy-proven acute rejection in the low-dose tacrolimus group was approximately half that of the standard-dose cyclosporine and low-dose cyclosporine groups, and a third of that in the low-dose sirolimus group. The low-dose cyclosporine group had more severe rejection episodes (>= grade II) compared with other groups. Acute rejection was associated with a 10 mL/min glomerular filtration rate (GFR) reduction and a 5.3% absolute increase in graft loss at 12 months. Overall, the highest GFR was found in both rejecters and non-rejecters receiving low-dose tacrolimus, both in an intent-to-treat analysis and in patients successfully treated according to the protocol. In Cox regression models, human leukocyte antigen (HLA) mismatches and expanded criteria donors increased the acute rejection risk, while recipient age, living related donor, and MMF dose were associated with a reduced risk. Acute rejection was associated with worse outcome but did not entirely explain the differences among the treatment groups. The 2 g MMF plus low-dose tacrolimus combination appears to be the most efficient of all regimens examined regardless of acute rejection.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a mycophenolate mofetil
653 a acute rejection
653 a cyclosporine
653 a sirolimus
653 a tacrolimus
7001 a Daloze, Pierre4 aut
7001 a Vitko, Stefan4 aut
7001 a Klempnauer, Juergen4 aut
7001 a Reyes-Acevedo, Rafael4 aut
7001 a Titiz, Izzet4 aut
7001 a Fricke, Lutz4 aut
7001 a Bernasconi, Corrado4 aut
7001 a Ekberg, Henriku Lund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-hek
7102 a Enheten för forskning kring njurfunktion och njursjukdomb Kirurgi4 org
7730 t Clinical Transplantationd : Wileyg 24:4, s. 500-509q 24:4<500-509x 1399-0012x 0902-0063
8564 u http://dx.doi.org/10.1111/j.1399-0012.2009.01093.xy FULLTEXT
8564 8u https://lup.lub.lu.se/record/1673935
8564 8u https://doi.org/10.1111/j.1399-0012.2009.01093.x

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy