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High Graft-versus-H...
High Graft-versus-Host Disease-Free, Relapse/Rejection-Free Survival and Similar Outcome of Related and Unrelated Allogeneic Stem Cell Transplantation for Aplastic Anemia : A Nationwide Swedish Cohort Study
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- Vaht, Krista, 1973 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Sweden; Gothenburg Univ, Sweden,Institutionen för medicin,Institute of Medicine
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- Göransson, Magnus (författare)
- Department of Pediatrics, The Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Dept Pediat, Gothenburg, Sweden
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- Carlson, Kristina (författare)
- Uppsala universitet,Hematologi,Uppsala University Hospital,Uppsala Univ Hosp, Sweden
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- Isaksson, Cecilia (författare)
- Department of Hematology, Cancer Centre, University Hospital, Umeå, Sweden,Univ Hosp, Canc Ctr, Dept Hematol, Umea, Sweden,Norrland University Hospital
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- Lenhoff, Stig (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden
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- Sandstedt, Anna (författare)
- Linköpings universitet,Institutionen för samhälls- och välfärdsstudier,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- Uggla, Bertil, 1962- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Section of Hematology Department of Medicine,Orebro Univ, Fac Med & Hlth, Sect Hematol, Dept Med, Orebro, Sweden
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- Winiarski, Jacek (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Ljungman, Per (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Andersson, Per-Ola, 1964 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,The County of Västra Götaland,Gothenburg Univ, Sweden; Sodra Alvsborg Hosp Boras, Sweden,Institutionen för medicin,Institute of Medicine
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- Brune, Mats, 1950 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Sweden; Gothenburg Univ, Sweden,Institutionen för medicin,Institute of Medicine
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- Engelska.
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier. - 1083-8791 .- 1523-6536. ; 25:10, s. 1970-1974
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Allogeneic stem cell transplantation (SCT) as primary treatment for aplastic anemia (AA) is being increasingly used. Yet, age, stem cell source, and donor type are important outcome factors. We have recently performed a nationwide cohort study of all patients with AA in Sweden diagnosed from 2000 to 2011 and now present outcome data on SCT patients. In total, 68 patients underwent SCT, and 63% of them had failed immunosuppressive therapy. We found that, with a median follow-up of 109 months (range, 35 to 192 months), 5-year overall survival (OS) for all patients was 86.8%, whereas graft-versus-host disease-free, relapse/rejection-free survival (GRFS) at 5 years was 69.1%. There was no survival impact regarding the donor type or stem cell source. Patients aged >= 40 years had a higher transplant-related mortality (29.4% versus 7.8%; P= .023), which translated into a lower 5-year OS: 70.6% versus 92.2% (A=.022) and a trend of lower GRFS (52.9% versus 74.5%; P = .069). In conclusion, we found in this real-world setting that both OS and GRFS were high, but SCT for patients with AA aged >= 40 years is problematic, and clinical trials addressing this issue are warranted. (C) 2019 American Society for Transplantation and Cellular Therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Aplastic anemia
- Allogenic stem cell transplantation
- Graft-versus-host disease-free
- Relapse/rejection-free survival
- Real-world data
- Allogenic stem cell transplantation
- Aplastic anemia
- Graft-versus-host disease-free
- Real-world data
- Relapse/rejection-free survival
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- art (ämneskategori)
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Vaht, Krista, 19 ...
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Göransson, Magnu ...
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Carlson, Kristin ...
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Isaksson, Cecili ...
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Lenhoff, Stig
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Sandstedt, Anna
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Uggla, Bertil, 1 ...
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Winiarski, Jacek
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Ljungman, Per
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Andersson, Per-O ...
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Brune, Mats, 195 ...
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