The Age of Olfactory Bulb Neurons in Humans

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Liebl, J. (author)

Bernard, S. (author)

Steier, P. (author)

Kutschera, W. (author)

Johnson, L. (author)

Landén, Mikael, 1966 (author): Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

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Related links:: http://www.cell.com/...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

Continuous turnover of neurons in the olfactory bulb is implicated in several key aspects of olfaction. There is a dramatic decline postnatally in the number of migratory neuroblasts en route to the olfactory bulb in humans, and it has been unclear to what extent the small number of neuroblasts at later stages contributes new neurons to the olfactory bulb. We have assessed the age of olfactory bulb neurons in humans by measuring the levels of nuclear bomb test-derived C-14 in genomic DNA. We report that C-14 concentrations correspond to the atmospheric levels at the time of birth of the individuals, establishing that there is very limited, if any, postnatal neurogenesis in the human olfactory bulb. This identifies a fundamental difference in the plasticity of the human brain compared to other mammals.

By the author/editor: Bergmann, O.; Liebl, J.; Bernard, S.; Alkass, K.; Yeung, M. S. Y.; Steier, P.; show more...; Kutschera, W.; Johnson, L.; Landén, Mikael, ...; Druid, H.; Spalding, K. L.; Frisen, J.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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