L773:1387 2877 OR L773:1875 8908
Sökning: L773:1387 2877 OR L773:1875 8908 > Does Treating Vascu...
- 1 av 659
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04089naa a2200541 4500 | |
| 001 | oai:DiVA.org:uu-397251 | |
| 003 | SwePub | |
| 008 | 191119s2018 | |||||||||||000 ||eng| | |
| 009 | oai:openarchive.ki.se:10616/46419 | |
| 009 | oai:prod.swepub.kib.ki.se:138564944 | |
| 022 | a 1387-2877 | |
| 024 | 7 | a 10616/464192 hdl |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3972512 URI |
| 024 | 7 | a https://doi.org/10.3233/JAD-1802882 DOI |
| 024 | 7 | a http://hdl.handle.net/10616/464192 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1385649442 URI |
| 040 | a (SwePub)uud (SwePub)kid (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Larsson, Susanna C.u Karolinska Institutet,Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)susla720 |
| 245 | 1 0 | a Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer's Disease? A Systematic Review and Meta-Analysis. |
| 264 | 1 | a Stockholm :b Karolinska Institutet, Institute of Environmental Medicine,c 2018 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: Epidemiological evidence has associated Alzheimer's disease (AD) with vascular risk factors (VRFs), but whether treatment of VRFs reduces the incidence of dementia and AD is uncertain.OBJECTIVE: To conduct a systematic review and meta-analysis to summarize available data on the impact of treatment of VRFs on dementia and AD incidence.METHODS: Pertinent studies published until 1 January 2018 were identified from PubMed. Both randomized controlled trials (RCT) and prospective studies that investigated the impact of treatment of VRFs on dementia or AD incidence were included.RESULTS: Eight RCTs and 52 prospective studies were identified. Antihypertensive treatment was associated with a non-significant reduced risk of dementia in RCTs (n = 5; relative risk [RR], 0.84; 95% confidence interval [CI], 0.69-1.02) and prospective studies (n = 3; RR, 0.77; 95% CI, 0.58-1.01) and with reduced AD risk in prospective studies (n = 5; RR = 0.78; 95% CI, 0.66-0.91). In prospective studies, treatment of hyperlipidemia with statins, but not nonstatin lipid-lowering agents, was associated with reduced risk of dementia (n = 17; RR, 0.77; 95% CI, 0.63-0.95) and AD (n = 13; RR, 0.86; 95% CI, 0.80-0.92). The single RCT on statins and dementia incidence showed no association. Data from one RCT and six prospective studies did not support a beneficial impact of antidiabetic drugs or insulin therapy on dementia risk.CONCLUSION: Current evidence indicates that antihypertensives and statins might reduce the incidence of dementia and AD. Further trials to determine the effect of VRF on AD are needed. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
| 653 | a Alzheimer’s disease | |
| 653 | a dementia | |
| 653 | a meta-analysis | |
| 653 | a prevention | |
| 653 | a prospective studies | |
| 653 | a randomized controlled trials | |
| 653 | a risk factors | |
| 653 | a systematic review | |
| 700 | 1 | a Markus, Hugh S4 aut |
| 710 | 2 | a Uppsala universitetb Ortopedi4 org |
| 710 | 2 | a Karolinska Institutet |
| 710 | 2 | a Karolinska Institutet |
| 773 | 0 | t Journal of Alzheimer's Diseased Stockholm : Karolinska Institutet, Institute of Environmental Medicineg 64:2, s. 657-668q 64:2<657-668x 1387-2877x 1875-8908 |
| 856 | 4 | u http://hdl.handle.net/10616/46419x primaryx Object in contextx freey FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397251 |
| 856 | 4 8 | u https://doi.org/10.3233/JAD-180288 |
| 856 | 4 8 | u http://hdl.handle.net/10616/46419 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138564944 |
Hitta via bibliotek
- Journal of Alzheimer's Disease (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 659
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Larsson, Susanna ...
- Markus, Hugh S
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Neurologi
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Geriatrik
- Artiklar i publikationen
- Journal of Alzhe ...
- Av lärosätet
- Uppsala universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
