A 5-year prospective study of health-related quality of life in irradiated head and neck cancer patients: three trends of HRQL over time

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Aghajanzadeh, SusanGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences (författare)

Purpose Head and neck cancer (HNC) is one of the fastest increasing cancer-types, where both disease and oncologic treatment have severe impact on health-related quality of life (HRQL). This study aimed to report HRQL prospectively up to 5-years following radiotherapy-treatment in HNC and to, if possible, identify trends in HRQL over time. Methods This prospective study followed 211 patients receiving curatively intended radiotherapy pre-diagnosis, 3-, 6-, 12- and 60-months post-radiotherapy completion. HRQL was measured using EORTC QLQ-C30 and EORTC QLQ-HN35. Results A deterioration three months post-radiotherapy was reported in 14/15 domains of EORTC QLQ-C30. Eight out of 12 domains had recovered to baseline-values at 12 months post-radiotherapy and remained unchanged up to study endpoint. Corresponding figures for EORTC QLQ-HN35 were deteriorations in 15/16 domains at three months post-radiotherapy, with recovery of 5 domain at 12-months, whereas the other 11 domains remained significantly worse at 5-years post-RT compared to baseline. Conclusion Following the deterioration in HRQL seen immediately following radiotherapy, the continued course of HRQL can be divided into three trends: short-term deterioration, long-term deterioration and long-term improvements. The combination of disease- and diagnosis-specific questionnaires is crucial when assessing HRQL in the HNC population.

Tuomi, Lisa,1985Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institutionen för kliniska vetenskaper,Institute of Neuroscience and Physiology,Institute of Clinical Sciences(Swepub:gu)xtuoli (författare)
Karlsson, Therese,1987Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xkther (författare)
Göteborgs universitetInstitutionen för kliniska vetenskaper (creator_code:org_t)

Ingår i:European Archives of Oto-Rhino-Laryngology: Springer Science and Business Media LLC280:5, s. 2617-220937-44771434-4726

Av författaren/redakt...: Aghajanzadeh, Su ...; Tuomi, Lisa, 198 ...; Karlsson, Theres ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Oto rhino laryng ...

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