L773:1573 2509 OR L773:0920 9964
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Association between symptomatic remission and functional outcome in first-episode schizophrenia
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- Bodén, Robert (author)
- Uppsala universitet,Psykiatri, Ulleråker, Akademiska sjukhuset,Psykiatri Ulleråker
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- Sundström, Johan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lindström, Eva (author)
- Lund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences,Department of Psychiatry and Forensic Psychiatry, Malmö University Hospital,Psykiatri Ulleråker
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- (creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
- In: Schizophrenia Research. - : Elsevier BV. - 0920-9964 .- 1573-2509. ; 107:2-3, s. 232-237
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Although operational criteria for remission in schizophrenia have recently been proposed, the association of this definition with broader functional outcome has not yet been established in first-episode patients. The severity criteria for remission consist of a score of mild or less on eight core symptoms of schizophrenia. We applied the severity criteria for remission to a sample of patients with first-episode schizophrenia (n = 76) in order to explore the association with functional outcome five years after first presentation to mental healthcare. We evaluated whether other factors than those included in the remission definition predicted good function in logistic regression models. The discriminatory capacities for remission and other factors for good function were tested using C-statistics. The proportions of remitters and non-remitters having good function were 73% and 17%, respectively. Furthermore, remitters had a higher level of subjective satisfaction with life. In comparison with non-remission, symptomatic remission was strongly associated with good function: odds ratio 13.2, 95% confidence interval, 4.3 to 40.3. A duration of untreated psychosis of three months or less as compared with a longer duration was associated with having good function at a five-year follow-up independently of remission status. The discriminatory capacity for symptomatic remission between having good function vs. not was acceptable (C-statistic = 0.78), which was significantly improved to an excellent discriminatory capacity by adding duration of untreated psychosis less than three months (C-statistic = 0.83, p = 0.04). In conclusion, core symptoms of schizophrenia have an important limiting effect on functioning and subjective life satisfaction in the early course of the illness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Remission
- Functional outcome
- First-episode
- Schizophrenia
- MEDICINE
- MEDICIN
- Schizophrenia
- First-episode
- Remission
- Functional outcome
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- ref (subject category)
- art (subject category)
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- Bodén, Robert
- Sundström, Johan
- Lindström, Eva
- Lindström, Leif
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