L773:1601 5215
Sökning: L773:1601 5215 > (2015-2019) > CGRP in a gene-envi...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02723naa a2200289 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:140619522 | |
| 003 | SwePub | |
| 008 | 240701s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1406195222 URI |
| 024 | 7 | a https://doi.org/10.1017/neu.2018.312 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Angelucci, F4 aut |
| 245 | 1 0 | a CGRP in a gene-environment interaction model for depression: effects of antidepressant treatment |
| 264 | c 2018-12-04 | |
| 264 | 1 | b Cambridge University Press (CUP),c 2019 |
| 520 | a ObjectiveGenetic and environmental factors interact in the development of major depressive disorder (MDD). While neurobiological correlates have only partially been elucidated, altered levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity (LI) in animal models and in the cerebrospinal fluid of depressed patients were reported, suggesting that CGRP may be involved in the pathophysiology and/or be a trait marker of MDD. However, changes in CGRP brain levels resulting from interactions between genetic and environmental risk factors and the response to antidepressant treatment have not been explored.MethodsWe therefore superimposed maternal separation (MS) onto a genetic rat model (Flinders-sensitive and -resistant lines, FSL/FRL) of depression, treated these rats with antidepressants (escitalopram and nortriptyline) and measured CGRP-LI in selected brain regions.ResultsCGRP was elevated in the frontal cortex, hippocampus and amygdala (but not in the hypothalamus) of FSL rats. However, MS did not significantly alter levels of this peptide. Likewise, there were no significant interactions between the genetic and environmental factors. Most importantly, neither escitalopram nor nortriptyline significantly altered brain CGRP levels.ConclusionOur data demonstrate that increased brain levels of CGRP are present in a well-established rat model of depression. Given that antidepressants have virtually no effect on the brain level of this peptide, our study indicates that further research is needed to evaluate the functional role of CGRP in the FSL model for depression. | |
| 700 | 1 | a Ellenbroek, BA4 aut |
| 700 | 1 | a El Khoury, A4 aut |
| 700 | 1 | a Mathe, AAu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Acta neuropsychiatricad : Cambridge University Press (CUP)g 31:2, s. 93-99q 31:2<93-99x 1601-5215x 0924-2708 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140619522 |
| 856 | 4 8 | u https://doi.org/10.1017/neu.2018.31 |
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