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Dissecting signalin...
Dissecting signaling and functions of adhesion G protein-coupled receptors
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Araç, Demet (author)
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Aust, Gabriela (author)
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Calebiro, Davide (author)
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Engel, Felix B (author)
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Formstone, Caroline (author)
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Goffinet, André (author)
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Hamann, Jörg (author)
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Kittel, Robert J (author)
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Liebscher, Ines (author)
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Lin, Hsi-Hsien (author)
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Monk, Kelly R (author)
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Petrenko, Alexander (author)
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Piao, Xianhua (author)
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Prömel, Simone (author)
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- Schiöth, Helgi B. (author)
- Uppsala universitet,Funktionell farmakologi
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Schwartz, Thue W (author)
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Stacey, Martin (author)
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Ushkaryov, Yuri A (author)
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Wobus, Manja (author)
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Wolfrum, Uwe (author)
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Xu, Lei (author)
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Langenhan, Tobias (author)
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(creator_code:org_t)
- 2012-12-07
- 2012
- English.
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In: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923 .- 1749-6632. ; 1276:1, s. 1-25
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- G protein-coupled receptors (GPCRs) comprise an expanded superfamily of receptors in the human genome. Adhesion class G protein-coupled receptors (adhesion-GPCRs) form the second largest class of GPCRs. Despite the abundance, size, molecular structure, and functions in facilitating cell and matrix contacts in a variety of organ systems, adhesion-GPCRs are by far the most poorly understood GPCR class. Adhesion-GPCRs possess a unique molecular structure, with extended N-termini containing various adhesion domains. In addition, many adhesion-GPCRs are autoproteolytically cleaved into an N-terminal fragment (NTF, NT, α-subunit) and C-terminal fragment (CTF, CT, β-subunit) at a conserved GPCR autoproteolysis-inducing (GAIN) domain that contains a GPCR proteolysis site (GPS). These two features distinguish adhesion-GPCRs from other GPCR classes. Though active research on adhesion-GPCRs in diverse areas, such as immunity, neuroscience, and development and tumor biology has been intensified in the recent years, the general biological and pharmacological properties of adhesion-GPCRs are not well known, and they have not yet been used for biomedical purposes. The "6th International Adhesion-GPCR Workshop," held at the Institute of Physiology of the University of Würzburg on September 6-8, 2012, assembled a majority of the investigators currently actively pursuing research on adhesion-GPCRs, including scientists from laboratories in Europe, the United States, and Asia. The meeting featured the nascent mechanistic understanding of the molecular events driving the signal transduction of adhesion-GPCRs, novel models to evaluate their functions, and evidence for their involvement in human disease.
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- By the author/editor
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Araç, Demet
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Aust, Gabriela
-
Calebiro, Davide
-
Engel, Felix B
-
Formstone, Carol ...
-
Goffinet, André
-
show more...
-
Hamann, Jörg
-
Kittel, Robert J
-
Liebscher, Ines
-
Lin, Hsi-Hsien
-
Monk, Kelly R
-
Petrenko, Alexan ...
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Piao, Xianhua
-
Prömel, Simone
-
Schiöth, Helgi B ...
-
Schwartz, Thue W
-
Stacey, Martin
-
Ushkaryov, Yuri ...
-
Wobus, Manja
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Wolfrum, Uwe
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Xu, Lei
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Langenhan, Tobia ...
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show less...
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Annals of the Ne ...
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Uppsala University