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Sökning: L773:1749 6632 OR L773:0077 8923 > (2010-2019) > Dissecting signalin...

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FältnamnIndikatorerMetadata
00003547naa a2200517 4500
001oai:DiVA.org:uu-190095
003SwePub
008130107s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1900952 URI
0247 a https://doi.org/10.1111/j.1749-6632.2012.06820.x2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Araç, Demet4 aut
2451 0a Dissecting signaling and functions of adhesion G protein-coupled receptors
264 c 2012-12-07
264 1b Wiley,c 2012
338 a print2 rdacarrier
520 a G protein-coupled receptors (GPCRs) comprise an expanded superfamily of receptors in the human genome. Adhesion class G protein-coupled receptors (adhesion-GPCRs) form the second largest class of GPCRs. Despite the abundance, size, molecular structure, and functions in facilitating cell and matrix contacts in a variety of organ systems, adhesion-GPCRs are by far the most poorly understood GPCR class. Adhesion-GPCRs possess a unique molecular structure, with extended N-termini containing various adhesion domains. In addition, many adhesion-GPCRs are autoproteolytically cleaved into an N-terminal fragment (NTF, NT, α-subunit) and C-terminal fragment (CTF, CT, β-subunit) at a conserved GPCR autoproteolysis-inducing (GAIN) domain that contains a GPCR proteolysis site (GPS). These two features distinguish adhesion-GPCRs from other GPCR classes. Though active research on adhesion-GPCRs in diverse areas, such as immunity, neuroscience, and development and tumor biology has been intensified in the recent years, the general biological and pharmacological properties of adhesion-GPCRs are not well known, and they have not yet been used for biomedical purposes. The "6th International Adhesion-GPCR Workshop," held at the Institute of Physiology of the University of Würzburg on September 6-8, 2012, assembled a majority of the investigators currently actively pursuing research on adhesion-GPCRs, including scientists from laboratories in Europe, the United States, and Asia. The meeting featured the nascent mechanistic understanding of the molecular events driving the signal transduction of adhesion-GPCRs, novel models to evaluate their functions, and evidence for their involvement in human disease.
7001 a Aust, Gabriela4 aut
7001 a Calebiro, Davide4 aut
7001 a Engel, Felix B4 aut
7001 a Formstone, Caroline4 aut
7001 a Goffinet, André4 aut
7001 a Hamann, Jörg4 aut
7001 a Kittel, Robert J4 aut
7001 a Liebscher, Ines4 aut
7001 a Lin, Hsi-Hsien4 aut
7001 a Monk, Kelly R4 aut
7001 a Petrenko, Alexander4 aut
7001 a Piao, Xianhua4 aut
7001 a Prömel, Simone4 aut
7001 a Schiöth, Helgi B.u Uppsala universitet,Funktionell farmakologi4 aut0 (Swepub:uu)helgschi
7001 a Schwartz, Thue W4 aut
7001 a Stacey, Martin4 aut
7001 a Ushkaryov, Yuri A4 aut
7001 a Wobus, Manja4 aut
7001 a Wolfrum, Uwe4 aut
7001 a Xu, Lei4 aut
7001 a Langenhan, Tobias4 aut
7102 a Uppsala universitetb Funktionell farmakologi4 org
7730 t Annals of the New York Academy of Sciencesd : Wileyg 1276:1, s. 1-25q 1276:1<1-25x 0077-8923x 1749-6632
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-190095
8564 8u https://doi.org/10.1111/j.1749-6632.2012.06820.x

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