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Sökning: L773:1755 5914 > (2011) > Effect on Mode of D...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003951naa a2200481 4500
001oai:lup.lub.lu.se:ca2e4382-ea6e-4491-a41b-a9734ff76a34
003SwePub
008160401s2011 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/18699532 URI
0247 a https://doi.org/10.1111/j.1755-5922.2010.00185.x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Krum, Henry4 aut
2451 0a Effect on Mode of Death of Heart Failure Treatment Started with Bisoprolol Followed by Enalapril, Compared to the Opposite Order: Results of the Randomized CIBIS III Trial
264 c 2011-02-24
264 1b Wiley,c 2011
520 a P>Background: Mode of death in chronic heart failure (CHF) may be of relevance to choice of therapy for this condition. Sudden death is particularly common in patients with early and/or mild/moderate CHF. beta-Blockade may provide better protection against sudden death than ACE inhibition (ACEI) in this setting. Methods: We randomized 1010 patients with mild or moderate, stable CHF and left ventricular ejection fraction < 35%, without ACEI, beta-blocker or angiotensin-receptor-blocker therapy, to either bisoprolol (n = 505) or enalapril (n = 505) for 6 months, followed by their combination for 6-24 months. The two strategies were blindly compared regarding adjudicated mode of death, including sudden death and progressive pump failure death. Results: During the monotherapy phase, 8 of 23 deaths in the bisoprolol-first group were sudden, compared to 16 of 32 in the enalapril-first group: hazard ratio (HR) for sudden death 0.50; 95% confidence interval (CI) 0.21-1.16; P = 0.107. At 1 year, 16 of 42 versus 29 of 60 deaths were sudden: HR 0.54; 95% CI 0.29-1.00; P = 0.049. At study end, 29 of 65 versus 34 of 73 deaths were sudden: HR 0.84; 95% CI 0.51-1.38; P = 0.487. Comparable figures for pump failure death were: monotherapy, 7 of 23 deaths versus 2 of 32: HR 3.43; 95% CI 0.71-16.53; P = 0.124, at 1 year, 13 of 42 versus 5 of 60: HR 2.57; 95% CI 0.92-7.20; P = 0.073, at study end, 17 of 65 versus 7 of 73: HR 2.39; 95% CI 0.99-5.75; P = 0.053. There were no significant between-group differences in any other fatal events. Conclusion: Initiating therapy with bisoprolol compared to enalapril decreased the risk of sudden death during the first year in this mild systolic CHF cohort. This was somewhat offset by an increase in pump failure deaths in the bisoprolol-first cohort.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Adrenergic beta-antagonists
653 a Angiotensin-converting enzyme inhibitors
653 a Drugs
653 a Heart failure
653 a Sudden death
7001 a van Veldhuisen, Dirk J.4 aut
7001 a Funck-Brentano, Christian4 aut
7001 a Vanoli, Emilio4 aut
7001 a Silke, Bernard4 aut
7001 a Erdmann, Erland4 aut
7001 a Follath, Ferenc4 aut
7001 a Ponikowski, Piotr4 aut
7001 a Goulder, Michael4 aut
7001 a Meyer, Wilfried4 aut
7001 a Lechat, Philippe4 aut
7001 a Willenheimer, Ronnieu Lund University,Lunds universitet,Kardiologiska klinikens forskargrupp,Forskargrupper vid Lunds universitet,Cardiology Research Group,Lund University Research Groups4 aut0 (Swepub:lu)medf-rw0
7102 a Kardiologiska klinikens forskargruppb Forskargrupper vid Lunds universitet4 org
7730 t Cardiovascular Therapeuticsd : Wileyg 29:2, s. 89-98q 29:2<89-98x 1755-5914
8564 u http://dx.doi.org/10.1111/j.1755-5922.2010.00185.xy FULLTEXT
8564 8u https://lup.lub.lu.se/record/1869953
8564 8u https://doi.org/10.1111/j.1755-5922.2010.00185.x

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