Sökning: L773:1945 7197 > Karlstads universitet > Reference ranges an...
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000 | 06467naa a2200553 4500 | |
001 | oai:DiVA.org:oru-68366 | |
003 | SwePub | |
008 | 180813s2018 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:su-161115 | |
009 | oai:DiVA.org:kau-69473 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-683662 URI |
024 | 7 | a https://doi.org/10.1210/jc.2018-008902 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1611152 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-694732 URI |
040 | a (SwePub)orud (SwePub)sud (SwePub)kau | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Derakhshan, Arashu Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlands,rasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherland4 aut |
245 | 1 0 | a Reference ranges and determinants of thyroid function during early pregnancy :b the SELMA study |
264 | c 2018-07-02 | |
264 | 1 | b Oxford University Press,c 2018 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:Exchange in Endocrinology Expertise (3E) program of the European Union of Medical Specialists (UEMS), Section and Board of Endocrinology ZOnMW VIDI 016.176.331 Erasmus MC MRACE grant County Council of Värmland, Sweden | |
520 | a Context: Establishing reference ranges as well as identifying and quantifying the determinants of thyroid function during pregnancy is important for proper clinical interpretation and optimizing research efforts. However, such data are sparse, specifically for (F)T3 measurements and most studies do not take into account thyroid antibodies or hCG.Objective: To determine reference ranges and to identify/quantify determinants of TSH, FT4, FT3, TT4 and TT3.Design, Setting and Participants: This study included 2,314 participants of the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study, a population-based prospective pregnancy cohort of mother-child pairs. Reference ranges were calculated by 2.5-97.5th percentiles after excluding TPOAb and/or TgAb positive women.Intervention: None.Main Outcome Measures: TSH, FT4, FT3, TT4 and TT3 in prenatal serum.Results: After exclusion of TPOAb positive women, reference range were: TSH: 0.11-3.48 mU/L, FT4: 11.6-19.4 pmol/L, FT3: 3.72-5.92 pg/mL, TT4: 82.4-166.2 pmol/L and TT3: 1.28-2.92 nmol/L. Additional exclusion of TgAb positive women did not change the reference ranges substantially. Exposure to tobacco smoke, as assessed by questionnaires and serum cotinine, was associated with lower TSH and higher FT3 and TT3. BMI and gestational age were the main determinants of TSH (only for BMI), FT4, FT3, TT4 and TT3.Conclusions: We show that the exclusion of TgAb positive women on top of excluding TPOAb positive women hardly affects clinical reference ranges. We identified various relevant clinical determinants of TSH, FT4, FT3, TT4 and TT3 which could reflect endocrine disrupting effects and/or effects on thyroid hormone transport or deiodination. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a Public Health Science | |
700 | 1 | a Shu, Huanu Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)hush5382 |
700 | 1 | a Broeren, Maarten A. C.u Laboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, Veldhoven, De Run, The Netherlands,Maxima Med Ctr, Lab Clin Chem & Haematol, NL-5504 DB Veldhoven, Netherlands4 aut |
700 | 1 | a de Poortere, Ralph A.u Laboratory of Clinical Chemistry and Haematology, Máxima Medical Centre, Veldhoven, De Run, The Netherlands,Maxima Med Ctr, Lab Clin Chem & Haematol, NL-5504 DB Veldhoven, Netherlands4 aut |
700 | 1 | a Wikström, Sverre,d 1978-u Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University4 aut0 (Swepub:oru)sewm |
700 | 1 | a Peeters, Robin P.u Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlands,rasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherland4 aut |
700 | 1 | a Demeneix, Barbarau Laboratoire d'Evolution des Régulations Endocriniennes, Muséum National d'Histoire Naturelle, Paris, France,Museum Natl Hist Nat, Lab Evolut Regulat Endocriniennes, Paris4 aut |
700 | 1 | a Bornehag, Carl-Gustaf,d 1957-u Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn Sch Med Mt Sinai, New York, NY4 aut0 (Swepub:kau)caguborn |
700 | 1 | a Korevaar, Tim I. M.u Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlands,Erasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherlands4 aut |
710 | 2 | a Academic Center for Thyroid Diseases, Erasmus MC, Rotterdam, The Netherlands; Department of internal Medicine, Erasmus MC, Rotterdam, The Netherlandsb rasmus MC, Acad Ctr Thyroid Dis, NL-3051 GE Rotterdam, Netherland4 org |
773 | 0 | t Journal of Clinical Endocrinology and Metabolismd : Oxford University Pressg 103:9, s. 3548-3556q 103:9<3548-3556x 0021-972Xx 1945-7197 |
856 | 4 | u https://academic.oup.com/jcem/article-pdf/103/9/3548/25685998/jc.2018-00890.pdf |
856 | 4 | u https://doi.org/10.1210/jc.2018-00890y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68366 |
856 | 4 8 | u https://doi.org/10.1210/jc.2018-00890 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-161115 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-69473 |
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