SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Çelikezen Fatih Çağlar)
 

Sökning: WFRF:(Çelikezen Fatih Çağlar) > (2023) > Synthesis, Characte...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004049naa a2200445 4500
001oai:DiVA.org:kth-350188
003SwePub
008240708s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3501882 URI
0247 a https://doi.org/10.1080/10406638.2023.22762432 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Akbas, Esvetu Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiye4 aut
2451 0a Synthesis, Characterization, Theoretical Studies and in Vitro Embriyotoxic, Genotoxic and Anticancer Effects of Novel Phenyl(1,4,6-Triphenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidin-5-yl)Methanone
264 c 2023
264 1b Informa UK Limited,c 2023
338 a print2 rdacarrier
500 a QC 20240708
520 a In this study, phenyl (1,4,6-triphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methanone was obtained by using the Biginelli reaction method. The structure of this compound was analyzed using elemental analysis, IR, 1H, and 13C NMR. The quantum chemical calculations (QCC) of this compound were performed density functional theory (DFT) method, 6–31 G (d, p) base set, and B3LYP functions with the Gaussian09W software package. Literature shows that pyrimidine-derived compounds have very active biological properties. For this reason, the biologically active properties of the synthesized compound were also examined. To determine embryotoxic, genotoxic, and cytotoxic effects of compound, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), lactate dehydrogenase (LDH) release, micronucleus (MN) and 8-OH-dG assays were carried out. On the other hand, pharmacokinetic and toxicity properties (ADMET) were predicted in silico via SwissADME and Protox-II web tools. In silico estimates of this compound used in the study showed that the compound has the covetable physicochemical properties for bioavailability. In conclusion, the obtained results of our study clearly showed that this compound exerted strong toxicity potential.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
653 a cytotoxicity
653 a DFT
653 a embryotoxicity
653 a genotoxicity
653 a Pyrimidin
653 a theoretical chemistry
7001 a Othman, Khdir A.u Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiye; Faculty of science and health, Department of chemistry, Koya University, Koy Sanjaq, Iraq4 aut
7001 a Çelikezen, Fatih Çağlaru Bitlis Eren University Faculty of Science and Letter, Department of Chemistry, Bitlis, Turkey4 aut
7001 a Aydogan Ejder, Nebahatu Department of Medical Microbiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey4 aut
7001 a Turkez, Hasanu Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey4 aut
7001 a Yapca, Omer Erkanu Department of Obstetrics and Gynecology, Atatürk University Faculty of Medicine, Erzurum, Turkey4 aut
7001 a Mardinoglu, Adilu KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, UK4 aut0 (Swepub:kth)u1t8kmr6
7102 a Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiyeb Department of Chemistry, Van Yuzuncu Yil University, Van, Türkiye; Faculty of science and health, Department of chemistry, Koya University, Koy Sanjaq, Iraq4 org
7730 t Polycyclic aromatic compounds (Print)d : Informa UK Limitedg , s. 1-18q <1-18x 1040-6638x 1563-5333
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-350188
8564 8u https://doi.org/10.1080/10406638.2023.2276243

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy