WFRF:(Akula Murali K)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04310naa a2200721 4500 | |
| 001 | oai:gup.ub.gu.se/241576 | |
| 003 | SwePub | |
| 008 | 240528s2016 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:133999320 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2415762 URI |
| 024 | 7 | a https://doi.org/10.1038/ni.34872 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1339993202 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Akula, Murali Ku Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Sahlgrenska Cancer Center,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut |
| 245 | 1 0 | a Control of the innate immune response by the mevalonate pathway |
| 264 | c 2016-06-06 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2016 |
| 520 | a Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, is the substrate for protein geranylgeranylation, a protein post-translational modification that is catalyzed by protein geranylgeranyl transferase I (GGTase I). Pyrin is an innate immune sensor that forms an active inflammasome in response to bacterial toxins. Mutations in MEFV (encoding human PYRIN) result in autoinflammatory familial Mediterranean fever syndrome. We found that protein geranylgeranylation enabled Toll-like receptor (TLR)-induced activation of phosphatidylinositol-3-OH kinase (PI(3)K) by promoting the interaction between the small GTPase Kras and the PI(3)K catalytic subunit p110 delta. Macrophages that were deficient in GGTase I or p110 delta exhibited constitutive release of interleukin 1 beta that was dependent on MEFV but independent of the NLRP3, AIM2 and NLRC4 inflammasomes. In the absence of protein geranylgeranylation, compromised PI(3)K activity allows an unchecked TLR-induced inflammatory responses and constitutive activation of the Pyrin inflammasome. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a phosphoinositide 3-kinase | |
| 653 | a protein prenylation | |
| 653 | a kinase-deficiency | |
| 653 | a cancer-therapy | |
| 653 | a ras | |
| 653 | a activation | |
| 653 | a cells | |
| 653 | a lipopolysaccharide | |
| 653 | a inflammasome | |
| 653 | a phosphorylation | |
| 653 | a Immunology | |
| 700 | 1 | a Shi, M.4 aut |
| 700 | 1 | a Jiang, Z. Z.4 aut |
| 700 | 1 | a Foster, C. E.4 aut |
| 700 | 1 | a Miao, D.4 aut |
| 700 | 1 | a Li, A. S.4 aut |
| 700 | 1 | a Zhang, X. M.4 aut |
| 700 | 1 | a Gavin, R. M.4 aut |
| 700 | 1 | a Forde, S. D.4 aut |
| 700 | 1 | a Germain, G.4 aut |
| 700 | 1 | a Carpenter, S.4 aut |
| 700 | 1 | a Rosadini, C. V.4 aut |
| 700 | 1 | a Gritsman, K.4 aut |
| 700 | 1 | a Chae, J. J.4 aut |
| 700 | 1 | a Hampton, R.4 aut |
| 700 | 1 | a Silverman, N.4 aut |
| 700 | 1 | a Gravallese, E. M.4 aut |
| 700 | 1 | a Kagan, J. C.4 aut |
| 700 | 1 | a Fitzgerald, K. A.4 aut |
| 700 | 1 | a Kastner, D. L.4 aut |
| 700 | 1 | a Golenbock, D. T.4 aut |
| 700 | 1 | a Bergö, Martin,d 1970u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Sahlgrenska Cancer Center,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xbmarl |
| 700 | 1 | a Wang, D. H.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
| 773 | 0 | t Nature Immunologyd : Springer Science and Business Media LLCg 17:8, s. 922-9q 17:8<922-9x 1529-2908x 1529-2916 |
| 856 | 4 | u https://dukespace.lib.duke.edu/dspace/bitstream/10161/12409/1/Akula_et_al-2016-Nature_Immunology.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/241576 |
| 856 | 4 8 | u https://doi.org/10.1038/ni.3487 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133999320 |
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