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Sökning: WFRF:(Albrecht Urs) > Schumann Gunter > Effects of the Circ...

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FältnamnIndikatorerMetadata
00004137naa a2200553 4500
001oai:DiVA.org:uu-161054
003SwePub
008111107s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1610542 URI
0247 a https://doi.org/10.1176/appi.ajp.2011.101115792 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Dong, Li4 aut
2451 0a Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking
264 1b American Psychiatric Association Publishing,c 2011
338 a print2 rdacarrier
520 a Objective: Circadian and stress-response systems mediate environmental changes that affect alcohol drinking. Psychosocial stress is an environmental risk factor for alcohol abuse. Circadian rhythm gene period 1(Per1) is targeted by stress hormones and is transcriptionally activated in corticotropin releasing factor-expressing cells. The authors hypothesized that Per1 is involved in integrating stress response and circadian rhythmicity and explored its relevance to alcohol drinking. Method: In mice, the effects of stress on ethanol intake in mPer1-mutant and wild-type mice were assessed. In humans, single nucleotide polymorphisms (SNPs) in hPer1 were tested for association with alcohol drinking behavior in 273 adolescents and an adult case-control sample of 1,006 alcohol-dependent patients and 1,178 comparison subjects. In vitro experiments were conducted to measure genotype-specific expression and transcription factor binding to hPer1. Results: The mPer1-mutant mice showed enhanced alcohol consumption in response to social defeat stress relative to their wild-type littermates. An association with the frequency of heavy drinking in adolescents with the hPer1 promoter SNP rs3027172 and with psychosocial adversity was found. There was significant interaction between the rs3027172 genotype and psychosocial adversity on this drinking measure. In a confirmatory analysis, association of hPer1 rs3027172 with alcohol dependence was shown. Cortisol-induced transcriptional activation of hPer1 was reduced in human B-lymphoblastoid cells carrying the risk genotype of rs3027172. Binding affinity of the transcription factor Snail1 to the risk allele of the hPer1 SNP rs3027172 was also reduced. Conclusions: The findings indicate that the hPer1 gene regulates alcohol drinking behavior during stressful conditions and provide evidence for underlying neurobiological mechanisms.
7001 a Bilbao, Ainhoa4 aut
7001 a Laucht, Manfred4 aut
7001 a Henriksson, Richard4 aut
7001 a Yakovleva, Tatjanau Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)tatia678
7001 a Ridinger, Monika4 aut
7001 a Desrivieres, Sylvane4 aut
7001 a Clarke, Toni-Kim4 aut
7001 a Lourdusamy, Anbarasu4 aut
7001 a Smolka, Michael N.4 aut
7001 a Cichon, Sven4 aut
7001 a Blomeyer, Dorothea4 aut
7001 a Treutlein, Jens4 aut
7001 a Perreau-Lenz, Stephanie4 aut
7001 a Witt, Stephanie4 aut
7001 a Leonardi-Essmann, Fernando4 aut
7001 a Wodarz, Norbert4 aut
7001 a Zill, Peter4 aut
7001 a Soyka, Michael4 aut
7001 a Albrecht, Urs4 aut
7001 a Rietschel, Marcella4 aut
7001 a Lathrop, Mark4 aut
7001 a Bakalkin, Georgyu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)gueba200
7001 a Spanagel, Rainer4 aut
7001 a Schumann, Gunter4 aut
7102 a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org
7730 t American Journal of Psychiatryd : American Psychiatric Association Publishingg 168:10, s. 1090-1098q 168:10<1090-1098x 0002-953Xx 1535-7228
8564 u http://doc.rero.ch/record/27113/files/alb_ecr.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-161054
8564 8u https://doi.org/10.1176/appi.ajp.2011.10111579

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