Wide-field mosaics of the corneal subbasal nerve plexus in Parkinsons disease using in vivo confocal microscopy

Belissario, Marco (författare): Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten

Utheim, Tor Paaske (författare): Oslo Univ Hosp, Norway; Sorlandet Hosp Arendal, Norway

Lagali, Neil (författare): Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Ögonkliniken US,Sorlandet Hosp Arendal, Norway

(creator_code:org_t)

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Abstract Ämnesord

Stäng

In vivo confocal microscopy (IVCM) is a non-invasive imaging technique facilitating real-time acquisition of images from the live cornea and its layers with high resolution (1-2 mu m) and high magnification (600 to 800-fold). IVCM is extensively used to examine the cornea at a cellular level, including the subbasal nerve plexus (SBNP). IVCM of the cornea has thus gained intense interest for probing ophthalmic and systemic diseases affecting peripheral nerves. One of the main drawbacks, however, is the small field of view of IVCM, preventing an overview of SBNP architecture and necessitating subjective image sampling of small areas of the SBNP for analysis. Here, we provide a high-quality dataset of the corneal SBNP reconstructed by automated mosaicking, with an average mosaic image size corresponding to 48 individual IVCM fields of view. The mosaic dataset represents a group of 42 individuals with Parkinsons disease (PD) with and without concurrent restless leg syndrome. Additionally, mosaics from a control group (n = 13) without PD are also provided, along with clinical data for all included participants.

Av författaren/redakt...: Badian, Reza A.; Allgeier, Stepha ...; Scarpa, Fabio; Andreasson, Matt ...; Bartschat, Andre ...; Mikut, Ralf; visa fler...; Colonna, Alessia; Belissario, Marc ...; Utheim, Tor Paas ...; Köhler, Bernd; Svenningsson, Pe ...; Lagali, Neil; visa färre...

Om ämnet

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