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Sökning: WFRF:(Alnæs Grethe Grenaker) > (2013) > SNP in TXNRD2 Assoc...

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FältnamnIndikatorerMetadata
00003699naa a2200445 4500
001oai:DiVA.org:uu-202417
003SwePub
008130624s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2024172 URI
0247 a https://doi.org/10.1016/j.ijrobp.2013.02.0252 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Edvardsen, Hege4 aut
2451 0a SNP in TXNRD2 Associated With Radiation-Induced Fibrosis :b A Study of Genetic Variation in Reactive Oxygen Species Metabolism and Signaling.
264 1b Elsevier BV,c 2013
338 a print2 rdacarrier
520 a PURPOSE: The aim of the study was to identify noninvasive markers of treatment-induced side effects. Reactive oxygen species (ROS) are generated after irradiation, and genetic variation in genes related to ROS metabolism might influence the level of radiation-induced adverse effects (AEs).METHODS AND MATERIALS: 92 breast cancer (BC) survivors previously treated with hypofractionated radiation therapy were assessed for the AEs subcutaneous atrophy and fibrosis, costal fractures, lung fibrosis, pleural thickening, and telangiectasias (median follow-up time 17.1 years). Single-nucleotide polymorphisms (SNPs) in 203 genes were analyzed for association to AE grade. SNPs associated with subcutaneous fibrosis were validated in an independent BC survivor material (n=283). The influence of the studied genetic variation on messenger ribonucleic acid (mRNA) expression level of 18 genes previously associated with fibrosis was assessed in fibroblast cell lines from BC patients.RESULTS: Subcutaneous fibrosis and atrophy had the highest correlation (r=0.76) of all assessed AEs. The nonsynonymous SNP rs1139793 in TXNRD2 was associated with grade of subcutaneous fibrosis, the reference T-allele being more prevalent in the group experiencing severe levels of fibrosis. This was confirmed in another sample cohort of 283 BC survivors, and rs1139793 was found significantly associated with mRNA expression level of TXNRD2 in blood. Genetic variation in 24 ROS-related genes, including EGFR, CENPE, APEX1, and GSTP1, was associated with mRNA expression of 14 genes previously linked to fibrosis (P≤.005).CONCLUSION: Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS, and maintenance of the intracellular redox balance.
653 a Molekylär medicin
653 a Molecular Medicine
7001 a Landmark-Høyvik, Hege4 aut
7001 a Reinertsen, Kristin V4 aut
7001 a Zhao, Xi4 aut
7001 a Grenaker-Alnæs, Grethe Irene4 aut
7001 a Nebdal, Daniel4 aut
7001 a Syvänen, Ann-Christine,d 1950-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär medicin,Molmed4 aut0 (Swepub:uu)anncsyva
7001 a Rødningen, Olaug4 aut
7001 a Alsner, Jan4 aut
7001 a Overgaard, Jens4 aut
7001 a Borresen-Dale, Anne-Lise4 aut
7001 a Fosså, Sophie D4 aut
7001 a Kristensen, Vessela N4 aut
7102 a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 org
7730 t International journal of radiation oncology, biology, physicsd : Elsevier BVg 86:4, s. 791-9q 86:4<791-9x 1879-355Xx 0360-3016
8564 u https://doi.org/10.1016/j.ijrobp.2013.02.025y Fulltext
8564 u https://doi.org/10.1016/j.ijrobp.2013.02.025
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-202417
8564 8u https://doi.org/10.1016/j.ijrobp.2013.02.025

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