A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children

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Fältnamn	Indikatorer	Metadata
000		03318naa a2200577 4500
001		oai:DiVA.org:su-136956
003		SwePub
008		161219s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1369562 URI
024	7	a https://doi.org/10.4137/GEG.S383072 DOI
040		a (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Amoako-Sakyi, Daniel4 aut
245	1 0	a A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children
264	1	c 2016
338		a print2 rdacarrier
520		a Malaria pathogenesis may be influenced by IgE responses and cytokine cross-regulation. Several mutations in the IL-4/STAT6 signaling pathway can alter cytokine cross-regulation and IgE responses during a Plasmodium falciparum malarial infection. This study investigated the relationship between a STAT6 intronic single-nucleotide polymorphism (rs3024974), total IgE, cytokines, and malaria severity in 238 Ghanaian children aged between 0.5 and 13 years. Total IgE and cytokine levels were measured by ELISA, while genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (RFLP). Compared with healthy controls, heterozygosity protected against clinical malaria: uncomplicated malaria (odds ratios [OR] = 0.13, P < 0.001), severe malarial anemia (OR = 0.18, P, 0.001), and cerebral malaria (OR = 0.39, P = 0.022). Levels of total IgE significantly differed among malaria phenotypes (P = 0.044) and rs3024974 genotypes (P = 0.037). Neither cytokine levels nor IL-6/IL-10 ratios were associated with malaria phenotypes or rs3024974 genotypes. This study suggests a role for rs3024974 in malaria pathogenesis and offers further insights into an IL-4/STAT6 pathway mutation in malaria pathogenesis.
650	7	a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653		a rs3024974
653		a STAT6
653		a SNP
653		a Ghana
653		a intron
653		a IgE
653		a malaria
700	1	a Adukpo, Selorme4 aut
700	1	a Kusi, Kwadwo A.4 aut
700	1	a Dodoo, Daniel4 aut
700	1	a Ofori, Michael F.4 aut
700	1	a Adjei, George O.4 aut
700	1	a Edoh, Dominic E.4 aut
700	1	a Asmah, Richard H.4 aut
700	1	a Brown, Charles4 aut
700	1	a Adu, Bright4 aut
700	1	a Obiri-Yeboah, Dorcas4 aut
700	1	a Futagbi, Godfred4 aut
700	1	a Abubakari, Sharif Buari4 aut
700	1	a Troye-Blomberg, Maritau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)marita
700	1	a Akanmori, Bartholomew D.4 aut
700	1	a Goka, Bamenla Q.4 aut
700	1	a Arko-Mensah, John4 aut
700	1	a Gyan, Ben A.4 aut
710	2	a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org
773	0	t Genetics and Epigeneticsg 8, s. 7-14q 8<7-14x 1179-237X
856	4	u https://doi.org/10.4137/GEG.S38307y Fulltext
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-136956
856	4 8	u https://doi.org/10.4137/GEG.S38307

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