WFRF:(Andreasson Ulf)
Search: WFRF:(Andreasson Ulf) > BACE1 inhibition in...
- 1 of 234
- Previous record
- Next record
- To hitlist
BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system.
-
- Mattsson, Niklas, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
- Rajendran, Lawrence (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
- show more...
- Lundkvist, Johan (author)
- Jacobson, Laura H (author)
- Perrot, Ludovic (author)
- Neumann, Ulf (author)
- Borghys, Herman (author)
- Mercken, Marc (author)
- Dhuyvetter, Deborah (author)
- Jeppsson, Fredrik (author)
- show less...
- (creator_code:org_t)
- 2012-02-06
- 2012
- English.
- In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 7:2
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- BACE1 is a key enzyme for amyloid-β (Aβ) production, and an attractive therapeutic target in Alzheimer's disease (AD). Here we report that BACE1 inhibitors have distinct effects on neuronal Aβ metabolism, inducing a unique pattern of secreted Aβ peptides, analyzed in cell media from amyloid precursor protein (APP) transfected cells and in cerebrospinal fluid (CSF) from dogs by immunoprecipitation-mass spectrometry, using several different BACE1 inhibitors. Besides the expected reductions in Aβ1-40 and Aβ1-42, treatment also changed the relative levels of several other Aβ isoforms. In particular Aβ1-34 decreased, while Aβ5-40 increased, and these changes were more sensitive to BACE1 inhibition than the changes in Aβ1-40 and Aβ1-42. The effects on Aβ5-40 indicate the presence of a BACE1 independent pathway of APP degradation. The described CSF Aβ pattern may be used as a pharmacodynamic fingerprint to detect biochemical effects of BACE1-therapies in clinical trials, which might accelerate development of novel therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Amyloid Precursor Protein Secretases
- antagonists & inhibitors
- Amyloid beta-Peptides
- metabolism
- Amyloid beta-Protein Precursor
- metabolism
- Animals
- Aspartic Acid Endopeptidases
- antagonists & inhibitors
- Cell Line
- Central Nervous System
- drug effects
- metabolism
- Cerebrospinal Fluid
- metabolism
- Chromatography
- Liquid
- Dimethyl Sulfoxide
- pharmacology
- Dogs
- Enzyme Inhibitors
- pharmacology
- Female
- Humans
- Immunoassay
- Immunoprecipitation
- Male
- Mass Spectrometry
- Tandem Mass Spectrometry
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 234
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Mattsson, Niklas ...
- Rajendran, Lawre ...
- Zetterberg, Henr ...
- Gustavsson, Mika ...
- Andreasson, Ulf, ...
- Olsson, Maria
- show more...
- Brinkmalm, Gunna ...
- Lundkvist, Johan
- Jacobson, Laura ...
- Perrot, Ludovic
- Neumann, Ulf
- Borghys, Herman
- Mercken, Marc
- Dhuyvetter, Debo ...
- Jeppsson, Fredri ...
- Blennow, Kaj, 19 ...
- Portelius, Erik, ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Neurology
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- PloS one
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
