Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

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Amundadottir, Laufey (author)

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

Article/chapterEnglish2009

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2009-08-02
Springer Science and Business Media LLC,2009
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LIBRIS-ID:oai:DiVA.org:umu-25443
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25443URI
https://doi.org/10.1038/ng.429DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

Added entries (persons, corporate bodies, meetings, titles ...)

Kraft, Peter (author)
Stolzenberg-Solomon, Rachael Z (author)
Fuchs, Charles S (author)
Petersen, Gloria M (author)
Arslan, Alan A (author)
Bueno-de-Mesquita, H Bas (author)
Gross, Myron (author)
Helzlsouer, Kathy (author)
Jacobs, Eric J (author)
Lacroix, Andrea (author)
Zheng, Wei (author)
Albanes, Demetrius (author)
Bamlet, William (author)
Berg, Christine D (author)
Berrino, Franco (author)
Bingham, Sheila (author)
Buring, Julie E (author)
Bracci, Paige M (author)
Canzian, Federico (author)
Clavel-Chapelon, Françoise (author)
Clipp, Sandra (author)
Cotterchio, Michelle (author)
de Andrade, Mariza (author)
Duell, Eric J (author)
Fox Jr, John W (author)
Gallinger, Steven (author)
Gaziano, J Michael (author)
Giovannucci, Edward L (author)
Goggins, Michael (author)
González, Carlos A (author)
Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
Hankinson, Susan E (author)
Hassan, Manal (author)
Holly, Elizabeth A (author)
Hunter, David J (author)
Hutchinson, Amy (author)
Jackson, Rebecca (author)
Jacobs, Kevin B (author)
Jenab, Mazda (author)
Kaaks, Rudolf (author)
Klein, Alison P (author)
Kooperberg, Charles (author)
Kurtz, Robert C (author)
Li, Donghui (author)
Lynch, Shannon M (author)
Mandelson, Margaret (author)
McWilliams, Robert R (author)
Mendelsohn, Julie B (author)
Michaud, Dominique S (author)
Olson, Sara H (author)
Overvad, Kim (author)
Patel, Alpa V (author)
Peeters, Petra H M (author)
Rajkovic, Aleksandar (author)
Riboli, Elio (author)
Risch, Harvey A (author)
Shu, Xiao-Ou (author)
Thomas, Gilles (author)
Tobias, Geoffrey S (author)
Trichopoulos, Dimitrios (author)
Van Den Eeden, Stephen K (author)
Virtamo, Jarmo (author)
Wactawski-Wende, Jean (author)
Wolpin, Brian M (author)
Yu, Herbert (author)
Yu, Kai (author)
Zeleniuch-Jacquotte, Anne (author)
Chanock, Stephen J (author)
Hartge, Patricia (author)
Hoover, Robert N (author)
Umeå universitetNäringsforskning (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC41, s. 986-9901061-40361546-1718

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By the author/editor: Amundadottir, La ...; Kraft, Peter; Stolzenberg-Solo ...; Fuchs, Charles S; Petersen, Gloria ...; Arslan, Alan A; show more...; Bueno-de-Mesquit ...; Gross, Myron; Helzlsouer, Kath ...; Jacobs, Eric J; Lacroix, Andrea; Zheng, Wei; Albanes, Demetri ...; Bamlet, William; Berg, Christine ...; Berrino, Franco; Bingham, Sheila; Buring, Julie E; Bracci, Paige M; Canzian, Federic ...; Clavel-Chapelon, ...; Clipp, Sandra; Cotterchio, Mich ...; de Andrade, Mari ...; Duell, Eric J; Fox Jr, John W; Gallinger, Steve ...; Gaziano, J Micha ...; Giovannucci, Edw ...; Goggins, Michael; González, Carlos ...; Hallmans, Göran; Hankinson, Susan ...; Hassan, Manal; Holly, Elizabeth ...; Hunter, David J; Hutchinson, Amy; Jackson, Rebecca; Jacobs, Kevin B; Jenab, Mazda; Kaaks, Rudolf; Klein, Alison P; Kooperberg, Char ...; Kurtz, Robert C; Li, Donghui; Lynch, Shannon M; Mandelson, Marga ...; McWilliams, Robe ...; Mendelsohn, Juli ...; Michaud, Dominiq ...; Olson, Sara H; Overvad, Kim; Patel, Alpa V; Peeters, Petra H ...; Rajkovic, Aleksa ...; Riboli, Elio; Risch, Harvey A; Shu, Xiao-Ou; Thomas, Gilles; Tobias, Geoffrey ...; Trichopoulos, Di ...; Van Den Eeden, S ...; Virtamo, Jarmo; Wactawski-Wende, ...; Wolpin, Brian M; Yu, Herbert; Yu, Kai; Zeleniuch-Jacquo ...; Chanock, Stephen ...; Hartge, Patricia; Hoover, Robert N; show less...

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