WFRF:(Aslam Rukhsana)
Sökning: WFRF:(Aslam Rukhsana) > (2020) > Thrombopoietin rece...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03498naa a2200421 4500 | |
| 001 | oai:lup.lub.lu.se:f845d38a-c511-472a-9bff-92630ca9115c | |
| 003 | SwePub | |
| 008 | 190625s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/f845d38a-c511-472a-9bff-92630ca9115c2 URI |
| 024 | 7 | a https://doi.org/10.1080/09537104.2019.16247092 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Kapur, Ricku University of Amsterdam,Academic Medical Center of University of Amsterdam (AMC)4 aut0 (Swepub:lu)ri1121ka |
| 245 | 1 0 | a Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP) |
| 264 | c 2019-05-30 | |
| 264 | 1 | b Informa UK Limited,c 2020 |
| 300 | a 4 s. | |
| 520 | a Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which autoantibodies and/or autoreactive T cells destroy platelets and megakaryocytes in the spleen and bone marrow, respectively. Thrombopoietin receptor agonists (TPO-RA e.g. Romiplostim and Eltrombopag) have made a substantial contribution to the treatment of patients with ITP, which are refractory to first-line treatments and approximately 30% demonstrate sustained elevated platelet counts after drug tapering. How TPO-RA induce these sustained responses is not known. We analyzed the efficacy of a murine TPO-RA in a well-established murine model of active ITP. Treatment with TPO-RA (10 ug/kg, based on pilot dose escalation experiments) significantly raised the platelet counts in ITP-mice. Immunomodulation was assessed by measuring serum IgG anti-platelet antibody levels; TPO-RA-treated mice had significantly reduced IgG anti-platelet antibodies despite the increasing platelet counts. These results suggest that TPO-RA is not only an efficacious therapy but also reduces anti-platelet humoral immunity in ITP. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
| 653 | a Immune thrombocytopenia (ITP) | |
| 653 | a immunomodulation | |
| 653 | a platelet antibodies | |
| 653 | a platelet counts | |
| 653 | a thrombopoietin receptor agonist (TPO-RA) | |
| 700 | 1 | a Aslam, Rukhsanau Saint Michael's Hospital4 aut |
| 700 | 1 | a Speck, Edwin R.u Saint Michael's Hospital4 aut |
| 700 | 1 | a Rebetz, Johan M.u Lund University,Lunds universitet,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Platelet Immunology,Lund University Research Groups4 aut0 (Swepub:lu)wbla-jre |
| 700 | 1 | a Semple, John W.u Lund University,Lunds universitet,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Platelet Immunology,Lund University Research Groups,University of Toronto,Saint Michael's Hospital4 aut0 (Swepub:lu)jo0201se |
| 710 | 2 | a University of Amsterdamb Academic Medical Center of University of Amsterdam (AMC)4 org |
| 773 | 0 | t Plateletsd : Informa UK Limitedg 31:3, s. 399-402q 31:3<399-402x 0953-7104x 1369-1635 |
| 856 | 4 | u http://dx.doi.org/10.1080/09537104.2019.1624709x freey FULLTEXT |
| 856 | 4 | u https://www.tandfonline.com/doi/pdf/10.1080/09537104.2019.1624709?needAccess=true |
| 856 | 4 8 | u https://lup.lub.lu.se/record/f845d38a-c511-472a-9bff-92630ca9115c |
| 856 | 4 8 | u https://doi.org/10.1080/09537104.2019.1624709 |
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- Kapur, Rick
- Aslam, Rukhsana
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