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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005715naa a2200985 4500
001oai:DiVA.org:umu-143557
003SwePub
008180103s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:137267718
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1435572 URI
0247 a https://doi.org/10.1093/ije/dyx1742 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1372677182 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Aleksandrova, Krasimira4 aut
2451 0a Physical activity, mediating factors and risk of colon cancer :b insights into adiposity and circulating biomarkers from the EPIC cohort
264 c 2017-09-05
264 1b Oxford University Press,c 2017
338 a print2 rdacarrier
520 a There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline. High physical activity was associated with a lower risk of colon cancer: relative risk a parts per thousand91 MET-h/week vs < 91 MET-h/week = 0.75 [95% confidence interval (CI): 0.57 to 0.96]. In mediation analyses, this association was accounted for by waist circumference: proportion explained effect (PEE) = 17%; CI: 4% to 52%; and the biomarkers soluble leptin receptor (sOB-R): PEE = 15%; 95% CI: 1% to 50% and 5-hydroxyvitamin D (25[OH]D): PEE = 30%; 95% CI: 12% to 88%. In combination, these factors explained 45% (95% CI: 20% to 125%) of the association. Beyond waist circumference, sOB-R and 25[OH]D additionally explained 10% (95% CI: 1%; 56%) and 23% (95% CI: 6%; 111%) of the association, respectively. Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Physical activity
653 a colon cancer
653 a mediating factors
653 a adiposity
653 a biomarkers
7001 a Jenab, Mazda4 aut
7001 a Leitzmann, Michael4 aut
7001 a Bueno-de-Mesquita, Bas4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Bamia, Christina4 aut
7001 a Lagiou, Pagona4 aut
7001 a Rinaldi, Sabina4 aut
7001 a Freisling, Heinz4 aut
7001 a Carayol, Marion4 aut
7001 a Pischon, Tobias4 aut
7001 a Drogan, Dagmar4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Jakszyn, Paula4 aut
7001 a Overvad, Kim4 aut
7001 a Dahm, Christina C.4 aut
7001 a Tjonneland, Anne4 aut
7001 a Bouton-Ruault, Marie-Christine4 aut
7001 a Kuehn, Tilman4 aut
7001 a Peppa, Eleni4 aut
7001 a Valanou, Elissavet4 aut
7001 a La Vecchia, Carlo4 aut
7001 a Palli, Domenico4 aut
7001 a Panico, Salvatore4 aut
7001 a Sacerdote, Carlotta4 aut
7001 a Agnoli, Claudia4 aut
7001 a Tumino, Rosario4 aut
7001 a May, Anne4 aut
7001 a van Vulpen, Jonna4 aut
7001 a Borch, Kristin Benjaminsen4 aut
7001 a Oyeyemi, Sunday Oluwafemi4 aut
7001 a Ramon Quiros, J.4 aut
7001 a Bonet, Catalina4 aut
7001 a Sanchez, Maria-Jose4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Navarro, Carmen4 aut
7001 a Barricarte, Aurelio4 aut
7001 a van Guelpen, Bethanyu Umeå universitet,Onkologi4 aut0 (Swepub:umu)beyvan99
7001 a Wennberg, Patriku Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)pawe0002
7001 a Key, Timothy J.4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nicholas4 aut
7001 a Assi, Nada4 aut
7001 a Ward, Heather A.4 aut
7001 a Aune, Dagfinn4 aut
7001 a Riboli, Elio4 aut
7001 a Boeing, Heiner4 aut
7102 a Karolinska Institutetb Onkologi4 org
7730 t International Journal of Epidemiologyd : Oxford University Pressg 46:6, s. 1823-1835q 46:6<1823-1835x 0300-5771x 1464-3685
8564 u https://academic.oup.com/ije/article-pdf/46/6/1823/22326266/dyx174.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143557
8564 8u https://doi.org/10.1093/ije/dyx174
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:137267718

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